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Calcineurin is a calcium/calmodulin-dependent protein phosphatase composed of two subunits, a regulatory subunit of calcineurin B (CNB) and a catalytic subunit of calcineurin A (CNA). PPP3CC is the y isoform of CNA located at the chromosome 8p21.3 region. To evaluate the association between PPP3CC and schizophrenia in the Taiwanese population, 10 single nucleotide polymorphism (SNP) markers across the gene were genotyped by the method of MALDI-TOF in 218 schizophrenia families with at least two affected siblings. One SNP (rs2272080) located around the exon 1 untranslated region was nominally associated with schizophrenia (P= 0.024) and significantly associated with the expression of PPP3CC in lymphoblast cell line; the TT and TG genotype had significantly higher relative expression levels than the GG genotype (P=0.0012 and 0.015, respectively). In further endophenotype stratification, the single locus of rs2272080 and the haplotypes of both two-SNP haplotype (rs7833266-rs2272080) and seven-SNP haplotype (rs2461491-rs2469758-rs2461489-rs2469770-rs2449340-rs1482337-rs2252471) showed significant associations with the subgroup of schizophrenia with deficits of the sustained attention as tested by the continuous performance test (CPT, P< 0.05) and the executive functioning as tested by the Wisconsin Card Sorting Test (WCST, P<0.05). The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia.

Titel:	More evidence supports the association of PPP3CC with schizophrenia
Autor/in / Beteiligte Person:	LIU, Y. L ; FANN, C. S. J ; TSUANG, M. M ; WU, J. Y ; JOU, Y. S ; FARAONE, S. V ; TSUANG, M. T ; CHEN, W. J ; WU, H-G. H ; LIU, C. M ; CHANG, C. C ; YANG, W. C ; HUNG, S. L ; YU, S. L ; HWANG, T. J ; HSIEH, M. H ; LIU, C. C
Link:	Volltext (PDF) View record from FRANCIS Archive
Zeitschrift:	Molecular psychiatry, Jg. 12 (2007), Heft 10, S. 966-974
Veröffentlichung:	Basingstoke: Nature Publishing Group, 2007
Medientyp:	academicJournal
Umfang:	print; 9; 52 ref
ISSN:	1359-4184 (print)
Schlagwort:	Psychose Psychosis Psicosis Calcineurine Calcineurin Calcineurina Schizophrénie Schizophrenia Esquizofrenia 8p21.3 PPP3CC SNP calcineurin A y calcineurin Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Psychopathologie. Psychiatrie Psychopathology. Psychiatry Etude clinique de l'adulte et de l'adolescent Adult and adolescent clinical studies Psychoses Psychologie. Psychanalyse. Psychiatrie Psychology. Psychoanalysis. Psychiatry PSYCHOPATHOLOGIE. PSYCHIATRIE Biochemistry, molecular biology, biophysics Biochimie, biologie moléculaire, biophysique Psychology, psychopathology, psychiatry Psychologie, psychopathologie, psychiatrie
Sonstiges:	Nachgewiesen in: FRANCIS Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Tawain, Province of China ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Tawain, Province of China ; Ju-Shan Mental Hospital, Taoyuan, Tawain, Province of China ; National Genotyping Center, Institute of Biomedical Sciences, Academia Sinica, Taipei, Tawain, Province of China ; Medical Genetics Research Center, Department of Psychiatry and Neuroscience & Physiology, SUNY Upstate Medical University, Syracuse, NY, United States ; Institute of Behavioral Genomics, University of California, San Diego, CA, United States ; Departments of Epidemiology and Psychiatry, Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard University, Boston, MA, United States ; Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Tawain, Province of China ; Department of Psychiatry, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Tawain, Province of China ; Department of Psychology, College of Science, National Taiwan University, Taipei, Tawain, Province of China ; Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Tawain, Province of China ; Department of Medical Research, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Tawain, Province of China Rights: Copyright 2007 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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More evidence supports the association of PPP3CC with schizophrenia