Persistent increases in the pool of doublecortin-expressing neurons in the hippocampus following spatial navigation training
In: Behavioural brain research, Jg. 188 (2008), Heft 2, S. 391-397
academicJournal
- print; 7; 35 ref
Zugriff:
In addition to its role in neuronal migration during embryonic development, doublecortin (DCX) plays a role in hippocampal neurogenesis across the lifespan. Hippocampal neurons exhibit a high degree of synaptic plasticity while they are in the DCX phase. While previous studies have reported that behavioral training on hippocampus-dependent tasks can enhance neuron survival, little was known about the stage of development of those neurons and, particularly, whether a large pool of the surviving new neurons remains in the DCX phase for a prolonged period after training. Here we report that spatial navigation training increases the pool of neurons that are in the DCX phase 4 weeks after training ended. Thus, the stock of DCX-expressing neurons in the hippocampus is affected by whether a hippocampus-dependent task has been encountered during the preceding few weeks.
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Persistent increases in the pool of doublecortin-expressing neurons in the hippocampus following spatial navigation training
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Autor/in / Beteiligte Person: | KEITH, Julian R ; PRIESTER, Carolina ; FERGUSON, Mitchell ; SAILING, Michael ; HANCOCK, Aneeka |
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Zeitschrift: | Behavioural brain research, Jg. 188 (2008), Heft 2, S. 391-397 |
Veröffentlichung: | Shannon: Elsevier Science, 2008 |
Medientyp: | academicJournal |
Umfang: | print; 7; 35 ref |
ISSN: | 0166-4328 (print) |
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