CBCL Pediatric Bipolar Disorder Profile and ADHD : Comorbidity and Quantitative Trait Loci Analysis
In: Journal of the American Academy of Child and Adolescent Psychiatry, Jg. 47 (2008), Heft 10, S. 1151-1157
academicJournal
- print; 7; 47 ref
Zugriff:
Objective: The pediatric bipolar disorder profilme of the Child Behavior Checklist (CBCL-PBD), a parent-completed measure that avoids clinician ideological bias, has proven useful in differentiating patients with attention-deficit/hyperactivity disorder (ADHD). We used CBCL-PBD profiles to distinguish patterns of comorbidity and to search for quantitative trait loci in a genomewide scan in a sample of multiple affected ADHD sibling pairs. Method: A total of 540 ADHD subjects ages 5 to 18 years were assessed with the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version and CBCL. Parents were assessed with the Schedule for Affective Disorders and Schizophrenia-Lifetime version supplemented by the Schedule for Affective Disorders and Schizophrenia for School-Age Children for disruptive behavioral disorders. Patterns of psychiatric comorbidity were contrasted based on the CBCL-PBD profile. A quantitative trait loci variance component analysis was used to identify potential genomic regions that may harbor susceptibility genes for the CBCL-PBD quantitative phenotype. Results: Bipolar spectrum disorders represented less than 2% of the overall sample. The CBCL-PBD classification was associated with increased generalized anxiety disorder (p = .001), oppositional defiant disorder (p = .008), conduct disorder (p = .003), and parental substance abuse (p = .005). A moderately significant linkage signal (multipoint maximum lod score = 2.5) was found on chromosome 2q. Conclusions: The CBCL-PBD profile distinguishes a subset of ADHD patients with significant comorbidity. Linkage analysis of the CBCL-PBD phenotype suggests certain genomic regions that merit further investigation for genes predisposing to severe psychopathology.
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CBCL Pediatric Bipolar Disorder Profile and ADHD : Comorbidity and Quantitative Trait Loci Analysis
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Autor/in / Beteiligte Person: | MCGOUGH, James J ; LOO, Sandra K ; MCCRACKEN, James T ; DANG, Jeffrey ; CLARK, Shaunna ; NELSON, Stanley F ; SMALLEY, Susan L |
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Zeitschrift: | Journal of the American Academy of Child and Adolescent Psychiatry, Jg. 47 (2008), Heft 10, S. 1151-1157 |
Veröffentlichung: | Hagerstown, MD: Lippincott, 2008 |
Medientyp: | academicJournal |
Umfang: | print; 7; 47 ref |
ISSN: | 0890-8567 (print) |
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