Gender and Genotype Modulation of the Association Between Lipid Levels and Depressive Symptomatology in Community-Dwelling Elderly (The ESPRIT Study)
In: Vascular Function in Depression in Older Adults, Jg. 68 (2010), Heft 2, S. 125-132
academicJournal
- print; 8; 47 ref
Zugriff:
Background: Lipids appear to mediate depressive vulnerability in the elderly; however, sex differences and genetic vulnerability have not been taken into account in previous prospective studies. Methods: Depression was assessed in a population of 1040 women and 752 men aged 65 years and older at baseline and after 7-year follow-up. Clinical level of depression (DEP) was defined as having either a score of 16 or higher on the Centre for Epidemiology Studies Depression scale or a diagnosis of current major depression on the Mini-International Neuropsychiatric Interview. Lipid levels, apolipoprotein E, and serotonin transporter linked promoter region (5-serotonin transporter gene linked promoter region) genotypes were evaluated at baseline. Results: Multivariate analyses adjusted by sociodemographic and behavioral variables, measures of physical health including ischemic pathologies, and genetic vulnerability indicated gender-specific associations between dyslipidemia and DEP, independent of the use of lipid-lowering agents or apolipoprotein E status. Men with low low-density lipoprotein cholesterol levels had twice the risk of prevalent and incident DEP, whereas in women low high-density lipoprotein cholesterol levels were found to be significantly associated with increased prevalent DEP (odds ratio = 1.5) only. A significant interaction was observed between low low-density lipoprotein-cholesterol and 5-serotonin transporter gene linked promoter region genotype, men with s/s or s/l genotype being at increased risk of DEP (odds ratio = 6.0 and 2.7, respectively). No significant gene-environment interaction was observed for women. Conclusions: DEP is associated with higher atherogenic risk in women (low high-density lipoprotein cholesterol), whereas the reverse is observed in men (low low-density lipoprotein cholesterol). Late-life depression may have a complex gender-specific etiology involving genetic vulnerability in men.
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Gender and Genotype Modulation of the Association Between Lipid Levels and Depressive Symptomatology in Community-Dwelling Elderly (The ESPRIT Study)
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Autor/in / Beteiligte Person: | ANCELIN, Marie-Laure ; CARRIERE, Isabelle ; BOULENGER, Jean-Philippe ; MALAFOSSE, Alain ; STEWART, Robert ; CRISTOL, Jean-Paul ; RITCHIE, Karen ; CHAUDIEU, Isabelle ; DUPUY, Anne-Marie ; KRISHNAN, K. Ranga Rama |
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Zeitschrift: | Vascular Function in Depression in Older Adults, Jg. 68 (2010), Heft 2, S. 125-132 |
Veröffentlichung: | New York, NY: Elsevier, 2010 |
Medientyp: | academicJournal |
Umfang: | print; 8; 47 ref |
ISSN: | 0006-3223 (print) |
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