Molecular-genetic correlates of self-harming behaviors in eating-disordered women: Findings from a combined Canadian-German sample
In: Progress in neuro-psychopharmacology & biological psychiatry, Jg. 35 (2011), Heft 1, S. 102-106
academicJournal
- print; 5; 1/2 p
Zugriff:
Across populations, findings suggest that rates of self-mutilation, suicidal acts, and other self-harming behaviors (SHBs) may be influenced by polymorphisms that code for activity of the serotonin transporter (e.g., 5HTTLPR) and the enzyme, monoamine oxidase A (e.g., MAOAuVNTR). SHBs being common in patients with Eating Disorders (EDs), we evaluated (in a large sample of eating-disordered women) relationships between triallelic 5HTTLPR and MAOAuVNTR variants, on the one hand, and SHBs, on the other. We had 399 eating-disordered women report on eating symptoms and lifetime history of SHBs, and provide blood samples for genotyping. Individuals carrying high-function MAOAuVNTR alleles reported a history of SHBs about twice as often as did carriers of low-function alleles. We obtained no comparable main effect of 5HTTLPR, or MAOAuVNTR x 5HTTLPR interaction effect. Genetic variations did not predict severity of eating symptoms. As in other populations, our findings link the MAOAuVNTR high-function alleles with increased risk of self-directed harm in bulimic females. We discuss theoretical and clinical ramifications of our results.
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Molecular-genetic correlates of self-harming behaviors in eating-disordered women: Findings from a combined Canadian-German sample
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Autor/in / Beteiligte Person: | STEIGER, Howard ; FICHTER, Manfred ; QUADFLIEG, Norbert ; BACHETZKY, Nadine ; BRUCE, Kenneth R ; JOOBER, Ridha ; BADAWI, Ghislaine ; RICHARDSON, Jodie ; GROLEAU, Patricia ; RAMOS, Cinthia ; ISRAEL, Mimi ; BONDY, Brigitta |
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Zeitschrift: | Progress in neuro-psychopharmacology & biological psychiatry, Jg. 35 (2011), Heft 1, S. 102-106 |
Veröffentlichung: | Amsterdam: Elsevier, 2011 |
Medientyp: | academicJournal |
Umfang: | print; 5; 1/2 p |
ISSN: | 0278-5846 (print) |
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