Optimized mobile phase for CEC of acetylsalicylic acid and its impurities using a methacrylate-based monolithic column

TANRET, Indiana ; MANGELINGS, Debby ; et al.

In: Monoliths, Jg. 34 (2011), Heft 16-17, S. 2284-2292

Online academicJournal - print; 9; 14 ref

Zugriff:

Full Text Finder (Volltext)

In the past few years, monolithic methacrylate-based columns have attracted some attention in separation science. The mobile-phase optimization on these columns for drug analysis has not yet been thoroughly examined. This paper evaluates the separation of acetylsalicylic acid and its impurities as a case study. First, the best pH was determined as 2.3. Methacrylate-based phases can be employed at such pH because they remain charged, necessary to generate electro-osmotic flow. Then, a suitable solvent strength was determined. Trifluoroacetic acid (0.1%) was added to the mobile phase to improve peak shapes. The optimal organic modifier composition was then determined, using isoeluotropic mobile phases, based on the theory of Snyder's solvent triangle. Quadratic models were built to predict the retention of the compounds at all mobile-phase compositions within the triangle. The predictions were tested and found appropriate. Eventually, a baseline separation of acetylsalicylic acid and its impurities was not obtained. However, it could be concluded that one can optimize the mobile phase on methacrylate-based monolithic columns in CEC using Snyder's solvent triangle approach.

Titel:	Optimized mobile phase for CEC of acetylsalicylic acid and its impurities using a methacrylate-based monolithic column
Autor/in / Beteiligte Person:	TANRET, Indiana ; MANGELINGS, Debby ; HEYDEN, Yvan Vander ; SVEC, Frantisek ; TENNIKOVA, Tatiana
Link:	Full Text Finder (Volltext) E-Journal im Bestand der UB Hagen? View record from FRANCIS Archive
Zeitschrift:	Monoliths, Jg. 34 (2011), Heft 16-17, S. 2284-2292
Veröffentlichung:	Weinheim: Wiley, 2011
Medientyp:	academicJournal
Umfang:	print; 9; 14 ref
ISSN:	1615-9306 (print)
Schlagwort:	Enzyme Enzima Inhibiteur enzyme Enzyme inhibitor Inhibidor enzima Oxidoreductases Prostaglandin-endoperoxide synthase Salicylés Salicylates Salicilatos Acide acétylsalicylique Acetylsalicylic acid Acetilsalicilico ácido Analgésique Analgesic Analgésico Analyse chimique Chemical analysis Análisis químico Analyse quantitative Quantitative analysis Análisis cuantitativo Anticoagulant Anticoagulante Antiinflammatoire non stéroïde Non steroidal antiinflammatory agent Antiinflamatorio no esteroide Antipyrétique Antipyretic Antipirético Colonne monolithique Monolithic column Columna monolítica Composition phase Phase composition Composición fase Contrôle pureté Purity control Verificación pureza Contrôle qualité Quality control Control de calidad Détecteur UV Ultraviolet detector Detector UV Electrochromatographie Electrochromatography Electrocromatografía Impureté Impurity Impureza Inhibiteur thromboagrégation Antiplatelet agent Inhibidor tromboagregación Méthacrylate copolymère Methacrylate copolymer Metacrilato copolímero Phase mobile Mobile phase Fase móvil pH Acetylsalicylic acid and impurities CEC Methacrylate-based monoliths Pharmaceutical analysis Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Pharmacologie générale General pharmacology Méthodes de contrôle Analysis Biochemistry, molecular biology, biophysics Biochimie, biologie moléculaire, biophysique Analytical chemistry Chimie analytique Pharmacology drugs Pharmacologie, galénique
Sonstiges:	Nachgewiesen in: FRANCIS Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Analytical Chemistry and Pharmaceutical Technology, Center for Pharmaceutical Research (CePhaR), Vrije Universiteit Brussel-VUB, Laarbeeklaan, Brussels, Belgium Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.