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Corticotropin-releasing factor (CRF) and serotonin are important transmitters of the pathophysiology of mood disorder. To clarify the mechanisms of action of lamotrigine (LTG) and carbamazepine (CBZ), we determined their effects on serotonin release associated with CRF in rat dorsal raphe nucleus (DRN) and median prefrontal cortex (mPFC) using dual-probe microdialysis. Neither perfusion with CRF1 nor CRF2 antagonists into DRN-affected serotonin release in DRN and mPFC. Perfusion of 10 μM CRF into DRN increased serotonin release in both regions, whereas 0.1 μM CRF decreased and had no effect on serotonin release in DRN and mPFC, respectively. Pre-perfusion with CRF 1 antagonist into DRN inhibited 0.1 μM CRF-induced serotonin reduction, whereas pre-perfusion with CRF2 antagonist in DRN inhibited 10 μM CRF-induced serotonin elevation, without affecting 0.1 μM CRF-induced serotonin reduction. LTG perfusion concentration dependently decreased serotonin releases in DRN and mPFC. Therapeutic and supratherapeutic concentrations of CBZ increased and decreased serotonin releases in both regions, respectively. Pre-perfusion with sub-therapeutic concentration LTG inhibited CRF1-induced serotonin reduction without affecting CRF2-induced serotonin release, whereas pre-perfusion with therapeutic concentration of LTG inhibited both CRF1- and CRF2-actions. In contrast, both therapeutic and supratherapeutic concentrations of CBZ inhibited CRF2-induced serotonin release without affecting CRF1-induced serotonin reduction. Neither LTG nor CBZ affected the CRF-induced cAMP production in cells over-expressing CRF1 and CRF2 receptors. This study demonstrated that inhibition of CRF2-receptor-mediated serotonergic transmission is a mechanism shared by LTG and CBZ, two clinically related compounds, whereas LTG but not CBZ inhibits CRF1-receptor-mediated serotonergic transmission. Therefore, these mechanisms may contribute to the clinical actions of these agents.

Titel:	Effect of lamotrigine and carbamazepine on corticotropin-releasing factor-associated serotonergic transmission in rat dorsal raphe nucleus
Autor/in / Beteiligte Person:	TANAHASHI, Shunske ; YAMAMURA, Satoshi ; NAKAGAWA, Masanori ; MOTOMURA, Eishi ; OKADA, Motohiro
Link:	Volltext (PDF) View record from FRANCIS Archive
Zeitschrift:	Psychopharmacologia, Jg. 220 (2012), Heft 3, S. 599-610
Veröffentlichung:	Berlin: Springer, 2012
Medientyp:	academicJournal
Umfang:	print; 12; 1 p.3/4
ISSN:	0033-3158 (print)
Schlagwort:	Carboxamide Carboxamida Composé tricyclique Tricyclic compound Compuesto tricíclico Dérivé de la dibenzoazépine Dibenzazepine derivatives Dibenzoazepina derivado Dérivé de la triazine Triazine derivatives Triazina derivado Encéphale Encephalon Encéfalo Facteur libération hormonale Hormone releasing factor Factor liberación hormonal Hormone hypothalamique Hypothalamic hormone Hormona hipotalámica Mammalia Neurotransmetteur Neurotransmitter Neurotransmisor Rodentia Système nerveux central Central nervous system Sistema nervioso central Vertebrata Animal Anticonvulsivant Anticonvulsant Anticonvulsivante CRF Corticotropin releasing factor HACT-RH Carbamazépine Carbamazepine Carbamazepina Cortex préfrontal Prefrontal cortex Corteza prefrontal Lamotrigine Lamotrigina Microdialyse Microdialysis Microdiálisis Normothymique Mood stabilizer Estabilizador humor Noyau dorsal Dorsal nucleus Núcleo dorsal Noyau raphé Raphe nucleus Núcleos del rafe Rat Rata Sérotonine Serotonin Serotonina Transmission sérotoninergique Serotoninergic transmission Transmisión serotoninérgica Cortex préfrontal médian Medial prefrontal cortex Corteza prefrontal mediana Dorsal raphe nucleus Sciences biologiques et medicales Biological and medical sciences Sciences medicales Medical sciences Pharmacologie. Traitements medicamenteux Pharmacology. Drug treatments Neuropharmacologie Neuropharmacology Psychoanaleptiques: stimulant snc, antidépresseur, nootrope, normothymique..., (maladie d'alzheimer) Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychologie. Psychanalyse. Psychiatrie Psychology. Psychoanalysis. Psychiatry Psychopharmacologie Psychopharmacology Psychoanaleptiques: stimulant SNC antidépresseur, nootrope, normothymique… Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer… Pharmacology drugs Pharmacologie, galénique Psychology, psychopathology, psychiatry Psychologie, psychopathologie, psychiatrie
Sonstiges:	Nachgewiesen in: FRANCIS Archive Sprachen: English Original Material: INIST-CNRS Document Type: Article File Description: text Language: English Author Affiliations: Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Brain Science and Animal Model Research Center (BSAM), Mie University, 2-174 Edobashi, Tsu, Mie 514-8507, Japan Rights: Copyright 2015 INIST-CNRS ; CC BY 4.0 ; Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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Effect of lamotrigine and carbamazepine on corticotropin-releasing factor-associated serotonergic transmission in rat dorsal raphe nucleus