TNF-alpha ―308G>A polymorphism is associated with suicide attempts in major depressive disorder
In: Journal of affective disorders, Jg. 150 (2013), Heft 2, S. 668-672
academicJournal
- print; 5; 3/4 p
Zugriff:
Background: Despite the substantial role of the cytokine network in depression and suicide, few studies have investigated the role of genetic polymorphisms of pro- and anti-inflammatory cytokines in suicide in major depressive disorder (MDD). The aim of this study was to investigate whether tumor necrosis factor-alpha (TNF-alpha) ―308G>A, interferon-gamma (IFN-gamma) +874A>T, and interleukin-10 (IL-10) ―1082A>G are associated with increased risk for suicide attempts in MDD. Methods: Among patients with MDD, 204 patients who had attempted suicide and 97 control patients who had not attempted suicide were recruited. A chi-square test was used to identify a possible risk genotype or allele type for suicide. A subsequent multivariate logistic regression analysis was conducted to investigate the influence of a risk genotype or allele type adjusted for other environmental factors. The lethality of the suicide attempt was also tested between genotype and allele types among suicidal patients with MDD. Results: The GG genotype of the TNF-alpha ―308G>A polymorphism was found to significantly increase risk for suicide attempt (adjusted OR = 2.630, 95% CI = 1.206 to 5.734). IFN-gamma +874A>T and IL-10 ―1082A>G were not associated with risk for suicide. Lethality of the suicide attempt was not associated with any of the three cytokine genotypes or allele types. Limitations: Limitations include a relatively small sample size and a cross-sectional design. Conclusions: TNF-alpha ―308G>A polymorphism is an independent risk factor for suicide attempts in MDD. Future studies should clarify the neural mechanisms by which the GG genotype of TNF-alpha ―308G>A influences suicide in MDD.
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TNF-alpha ―308G>A polymorphism is associated with suicide attempts in major depressive disorder
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Autor/in / Beteiligte Person: | KIM, Yong-Ku ; HONG, Jin-Pyo ; HWANG, Jung-A ; LEE, Heon-Jeong ; YOON, Ho-Kyoung ; LEE, Bun-Hee ; JUNG, Han-Yong ; HAHN, Sang-Woo ; NA, Kyoung-Sae |
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Zeitschrift: | Journal of affective disorders, Jg. 150 (2013), Heft 2, S. 668-672 |
Veröffentlichung: | Oxford: Elsevier, 2013 |
Medientyp: | academicJournal |
Umfang: | print; 5; 3/4 p |
ISSN: | 0165-0327 (print) |
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