Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs?
In: Acta psychiatrica scandinavica, Jg. 130 (2014), Heft 1, S. 40-45
Online
academicJournal
- print; 6; 30 ref
Zugriff:
Objective: The aim of this study was to compare the differential response to amisulpride in patients with paranoid versus disorganized schizophrenia. Method: We reanalyzed the original data from five different randomized drug trials comparing Brief Psychiatric Rating Scale (BPRS) scores in a database containing 427 paranoid and 296 disorganized patients with schizophrenia. Results: Both the disorganized and the paranoid group showed a substantial improvement of the BPRS total score within the first 4 weeks. In the paranoid group, mean (±SD) BPRS reduction was 16.9 (±14.6) (t = 24.06, df = 426, P < 0.001) and in the disorganized group 17.0 (±15.9) (t = 18.49, df = 295, P < 0.001). An analysis of covariance (ANCOVA) controlling for BPRS at baseline and the influence of different trial protocols showed significant differences between diagnostic groups (F = 13.47, df = 1, P < 0.001), Cohen's D 0.31 (CI = 0.16―0.46). Paranoid patients improved by 4.8 BPRS points more than disorganized patients (adjusted means 18.90 (CI = 17.33―20.37) for the paranoid and 14.1 (CI = 12.04 ― 16.11) for the disorganized group. Conclusion: We conclude that amisulpride is effective in disorganized as well as in paranoid schizophrenia, but that symptom reduction in the disorganized subtype is less pronounced.
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Do patients with paranoid and disorganized schizophrenia respond differently to antipsychotic drugs?
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Autor/in / Beteiligte Person: | CORVES, C ; ENGEL, R. R ; DAVIS, J ; LEUCHT, S |
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Zeitschrift: | Acta psychiatrica scandinavica, Jg. 130 (2014), Heft 1, S. 40-45 |
Veröffentlichung: | Oxford: Blackwell, 2014 |
Medientyp: | academicJournal |
Umfang: | print; 6; 30 ref |
ISSN: | 0001-690X (print) |
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