Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women
In: European Journal of Clinical Nutrition, Jg. 59 (2005-10-01), Heft 10, S. 1105
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Zugriff:
Objective: To study the relationships of molecularly defined lactose malabsorption (LM) and self-reported lactose intolerance (LI) to bone mineral density (BMD) and fractures among Finnish postmenopausal women. Design: A cross-sectional study of two cohorts. Setting: Helsinki University Central Hospital. Subjects: One cohort was population-based and comprised 453 women, aged 62-78 (mean 69) y. Another comprised 52 women, aged 69-85 (mean 75) y, with osteoporotic fractures and 59 control women, aged 69-83 (mean 74) y, without osteoporosis. Methods: A single nucleotide polymorphism of the lactase (LCT) gene at chromosome 2q21-22 was studied. It shows complete association with intestinal disaccharidase activity, with the genotype CC[sub.-13 910] meaning adult-type hypolactasia (primary LM) and the genotypes CT[sub.-13 910] and TT[sub.-13 910] lactose absorption. BMD of the heel was measured by dual-energy X-ray absorptiometry (DXA). Results: In the population-based cohort, 16.0% of women had self-reported LI but only 15.3% of them had the CC[sub.-13 910] genotype. Calcium intake from dairy products (P=0.10) and BMD, adjusted for age, weight, height, exercise, smoking, and estrogen use (P=0.71) were similar for the genotypes. Women with self-reported LI had reduced calcium intake from dairy products (P [less than] 0.0001) but they were more frequent users of calcium supplements than lactose-tolerants (P [less than] 0.0001). Adjusted BMD was similar for lactose intolerant and tolerant women (P=0.60). Of 104 women with previous fracture in the population-based cohort, 13.5% had the CC[sub.-13 910] genotype, which did not differ from the prevalence of 19.3% among 347 women without fractures (P=0.29). The frequency of the CC[sub.-13 910] genotype (23.1%) for 52 women with established osteoporosis was similar as for 59 control women (15.3%) (P=0.19). Conclusion: Molecularly defined LM and self-reported LI are not risk factors for osteoporosis, if calcium intake from diet and/or supplements remains sufficient. Our study confirms the poor correlation between self-reported LI and LM established by different techniques. Sponsorhip: Supported by the Research Funding from Helsinki University Central Hospital (Erityisvaltionosuus) and by the Miina Sillanp#228;#228; Foundation, Helsinki, Finland. European Journal of Clinical Nutrition (2005) 59, 1105-1111. doi: 10.1038/sj.ejcn.1602219; published online 6 July 2005 Keywords: lactase, lactose intolerance, lactose malabsorption, genotype, bone mineral density, fractures, osteoporosis
Author(s): N Enattah [1]; T Pekkarinen [2]; M J Valimaki [3]; E Loyttyniemi [4]; I Jarvela [1, 5] Introduction Osteoporosis is a multi-factorial disease caused by both genetic and environmental [...]
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Genetically defined adult-type hypolactasia and self-reported lactose intolerance as risk factors of osteoporosis in Finnish postmenopausal women
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Autor/in / Beteiligte Person: | Enattah, N ; Pekkarinen, T ; Valimaki, M J ; Loyttyniemi, E ; Jarvela, I |
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Zeitschrift: | European Journal of Clinical Nutrition, Jg. 59 (2005-10-01), Heft 10, S. 1105 |
Veröffentlichung: | 2005 |
Medientyp: | academicJournal |
ISSN: | 0954-3007 (print) |
DOI: | 10.1038/sj.ejcn.1602219 |
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