Universal Patterns of Selection in Cancer and Somatic Tissues
In: Cell, Jg. 171 (2017-11-16), Heft 5, S. 1029
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To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.cell.2017.09.042 Byline: Inigo Martincorena [im3@sanger.ac.uk] (1,6,*), Keiran M. Raine (1), Moritz Gerstung (2), Kevin J. Dawson (1), Kerstin Haase (3), Peter Van Loo (3,4), Helen Davies (1), Michael R. Stratton (1), Peter J. Campbell [pc8@sanger.ac.uk] (1,5,**) Keywords cancer; genomics; evolution; mutations; selection Highlights * Unlike the germline, somatic cells evolve predominantly by positive selection * Nearly all (~99%) coding mutations are tolerated and escape negative selection * Exome-wide estimates of the total number of driver coding mutations per tumor * Half of the coding driver mutations occur outside of known cancer genes Summary Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures of selection in cancer evolution are lacking. We adapted methods from molecular evolution and applied them to 7,664 tumors across 29 cancer types. Unlike species evolution, positive selection outweighs negative selection during cancer development. On average, Author Affiliation: (1) Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK (2) European Molecular Biology Laboratory, European Bioinformatics Institute EMBL-EBI, Hinxton CB10 1SD, UK (3) The Francis Crick Institute, London NW1 1AT, UK (4) Department of Human Genetics, University of Leuven, Leuven 3000, Belgium (5) Department of Haematology, University of Cambridge, Cambridge CB2 2XY, UK * Corresponding author Article History: Received 13 April 2017; Revised 9 August 2017; Accepted 22 September 2017 (miscellaneous) Published: October 19, 2017 (footnote)6 Lead Contact
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Universal Patterns of Selection in Cancer and Somatic Tissues
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Autor/in / Beteiligte Person: | Martincorena, Inigo ; Raine, Keiran M. ; Gerstung, Moritz ; Dawson, Kevin J. ; Haase, Kerstin ; Van Loo, Peter ; Davies, Helen ; Stratton, Michael R. ; Campbell, Peter J. |
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Zeitschrift: | Cell, Jg. 171 (2017-11-16), Heft 5, S. 1029 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 0092-8674 (print) |
DOI: | 10.1016/j.cell.2017.09.042 |
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