Regulation effect of djulis hull on blood lipids in hyperlipidemic hamsters
2017
Hochschulschrift
Zugriff:
105
Heart disease and cerebrovascular disease are the second and third leading cause of death in Taiwan in 2015. Many studies showed that the most important factor leading to cardiovascular-related diseases is atherosclerosis, and the main caused by atherosclerosis is high blood cholesterol levels. Over the years, the risk of cardiovascular disease associated with population continues to increase, so the healthy diet and exercise have become one of the important issues. Djulis (Chenopodium formosanum) is a native cereal plant in Taiwan, and the djulis hull (DH) was found to be its major source of antioxidant compound. Studies showed that it possesses several active components with hypolipidemic activities, such as dietary fiber and polyphenol compounds. The objective of this investigation was to evaluate the regulation effects of DH in blood lipid levels to achieve the prevention of atherosclerosis effect. Five weeks old hamsters were randomly divided into five groups: (1) control group (C), (2) hyperlipidemic group (high fat diet containing 0.2% cholesterol; HFC), (3) low-dose DH group (HFC diet and treated with 50 mg/kg/day DH; LDH), medium-dose DH group (HFC diet and treated with 100 mg/kg/day DH; MDH), high-dose DH group (HFC diet and treated with 250 mg/kg/day DH; HDH). After 6 weeks of feeding study, the results showed that levels of triglyceride (TG: 356±16 mg/dl), total cholesterol (TC: 463±88 mg/dl) and low-density lipoprotein cholesterol (LDL-C: 153±15 mg/dl) in serum were significantly increased in HFC group compared with C group (TG: 128±15 mg/dl; TC: 130±10 mg/dl; LDL-C: 21.3±5 mg/dl). After DH administration, the results showed that levels of TG (LDH: 260±65 mg/dl; MDH: 226±70 mg/dl; HDH: 201±29 mg/dl), TC (LDH: 280±49 mg/dl; MDH: 277±37 mg/dl; HDH: 251±39 mg/dl) and LDL-C (LDH: 133±55 mg/dl; MDH: 133±1 mg/dl; HDH: 79±33 mg/dl) in serum were significantly reduced by DH administration compared with those of HFC group. Moreover, levels of TG and TC in liver and feces were lower than HFC group. These results indicate that DH possesses hypolipidemic potential to be a benefit functional food to prevent high fat/high cholesterol diet-induced hyperlipidemia.
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Regulation effect of djulis hull on blood lipids in hyperlipidemic hamsters
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Autor/in / Beteiligte Person: | Chen, Yi-Zhen ; 陳詣蓁 |
Link: | |
Veröffentlichung: | 2017 |
Medientyp: | Hochschulschrift |
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