The Impact of Lower-limb Heating on Exercise Capacity, Vascular and Metabolic function in patients with Heart Failure
2022
Online
Elektronische Ressource
Zugriff:
Full Text
Thesis (Masters)
Master of Medical Research (MMedRes)
School of Pharmacy & Med Sci
Griffith Health
Heart failure (HF) − whilst primarily classified as an impaired ability to pump blood − also negatively impacts peripheral vascular function and blunts energy production (metabolism) in skeletal muscle. When combined, these factors result in a decreased exercise tolerance and, subsequently, a reduced quality of life. Recent studies have shown that lower-limb heating improves measures of vascular function in a healthy older population, and increases endurance capacity and vascular function in a peripheral artery disease population. However, the effects of lower-limb heating have never been studied in individuals with HF. The purpose of the study was to examine the impact of lower-limb heating on endurance exercise capacity, vascular function (blood flow and vascular tone) and muscle metabolism (skeletal muscle oxidation and tissue oxygen saturation) in individuals with HF. Thirteen individuals (71.3 ± 7.9 yrs) with heart failure with reduced ejection fraction (Ejection fraction, 31.6 ± 7.5 %) immersed both their lower-limbs into the bath - to a level just below the knee - for 45 minutes at either thermoneutral control (CON) (30°C) or hot (42°C) temperature (LLH). Femoral artery blood flow (Doppler ultrasound) was measured during immersion for both conditions. Postimmersion, individuals completed either an endurance shuttle walk test (ESWT) with a secondary outcome measure of peripheral tissue saturation index (TSI%, via Near-infrared spectroscopy) or alternatively, their arterial stiffness (pulse wave velocity) and peripheral muscle oxidative capacity was measured. Femoral blood flow velocity (193%), and subsequently, blood flow (270%) and mean shear rate (160%) increased continuously through LLH, whilst no improvement was noted in CON. Similarly, time to exhaustion (CON, 381.8 ± 57.3 s; LLH, 525.3 ± 60.5 s; p < 0.01) and the total distance walked (CON, 603.9 ± 95.7 m; LLH, 816.2 ± 91.8 m; p < 0.01) in the ESWT also increased in response to LLH. After LLH, TSI% was g
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The Impact of Lower-limb Heating on Exercise Capacity, Vascular and Metabolic function in patients with Heart Failure
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Veröffentlichung: | 2022 |
Medientyp: | Elektronische Ressource |
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