Bone Tissue Regeneration by Using Melt Electrospinning Writing (MEW)
2020
Online
Elektronische Ressource
Biomaterial scaffolds engineered to facilitate osteogenesis which can subsequently remodel in a similar fashion to that of natural tissue, is an ideal clinical strategy for treating bone defects in the maxillofacial region. This study has developed, using a novel melt electrowriting (MEW) technique, various graded porous polycaprolactone (PCL) scaffolds able to imitate the bimodal structure of cortical and cancellous bone tissue in terms of their morphological pore structure. These scaffolds were subsequently shown to facilitate the proliferation of osteoblasts with significant alkaline phosphatase (ALP) activity. Scaffolds with a staggered architecture i.e. those where the corresponding fibers in different layers are offset horizontally during the printing process, increases the number of contact points, enables larger pores, facilitates cell attachment and creates a highly porous structure with interconnected networks favourable for improved cell migration and vascularization. MEW is a relatively new technology that fills a gap between conventional fused deposition modelling (FDM) 3D printing and solution electrospinning by affording significantly better control over the fabrication of the porosity in scaffolds. This is due to the high-resolution during printing of the fibers which enables small pore sizes in the desired porosity. PCL polymer with its advantages of less immunoreactivity following implantation and mechanically suitability for the support of bone cells, has flexibility in design and is widely used in bone applications. However poor bioactivity and cellular affinity as well as long-term degradation issues with PCL have been reported. A promising solution to overcome these drawbacks is fiber surface modification such as coating with bioactive inorganic components. hydroxyapatite (HAP) is the most stable form of calcium phosphate (CaP) used to improve the hydrophobic characteristics of PCL and enhance the binding affinity to the host tissue and promote
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Dentistry&Oral Hlth
Griffith Health
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Bone Tissue Regeneration by Using Melt Electrospinning Writing (MEW)
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Veröffentlichung: | 2020 |
Medientyp: | Elektronische Ressource |
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