KXS Balances the Tryptophan Metabolism in Mild to Moderate Depressed Patients and Chronic Restraint Stress Induced Depressive Rats
2022
Online
Elektronische Ressource
Yuanbo Wang1,2 *, Xia Li1,2 *, Rui Jing,2 Wenshan Yang,1,2 Yichen Wang,1,2 Chaochen Wang,1,2 Lei Yao,1,2 Xiaoming Cui,3 Yuan Hu2 1Graduate School of PLA General Hospital, Beijing, 100853, Peopleâs Republic of China; 2Department of Pharmacy, Medical Supplies Center of PLA General Hospital, Beijing, 100853, Peopleâs Republic of China; 3Department of Health Medicine, The Third Medical Center of PLA General Hospital, Beijing, 100039, Peopleâs Republic of China*These authors contributed equally to this workCorrespondence: Xiaoming Cui, Department of Health Medicine, The Third Medical Center of PLA General Hospital, Beijing, 100039, Peopleâs Republic of China, Email 18611206336@163.com Yuan Hu, Department of Pharmacy, Medical Supplies Center of PLA General Hospital, No. 28 FuXing Road, Beijing, 100853, Peopleâs Republic of China, Email huyuan1980619@126.comPurpose: Tryptophan metabolism is involved in the etiology and exacerbation of depressive disorders. Kai-Xin-San (KXS), a traditional Chinese medicine formula, has been widely used to treat depression and modulate serotonin simultaneously, but how it regulates depressive-like behavior by shifting the balance of the tryptophan-serotonin metabolism and kynurenine pathway remains vague.Patients and Methods: Ten participants with mild to moderate depression treated with KXS (KXS preparation) were analyzed in this study. Depression rating scale score and the concentration of serum tryptophan, 5-hydroxytryptophan and kynurenine was measured at baseline and the endpoint of KXS treatment. To explore the specific regulatory mechanism of KXS in tryptophan metabolism, the chronic restraint stress (CRS) was used to induce depressive-like syndrome in rats and the hippocampus level of tryptophan, 5-hydroxytryptophan, kynurenine with downstream metabolites (kynurenic acid, quinolinic acid) and key enzymes (indoleamine 2,3-dioxygenase, kynurenine 3-monooxygenase, kynurenine aminotransferase) were analy
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KXS Balances the Tryptophan Metabolism in Mild to Moderate Depressed Patients and Chronic Restraint Stress Induced Depressive Rats
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Veröffentlichung: | 2022 |
Medientyp: | Elektronische Ressource |
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