Investigating the biosynthesis of Sch-642305 in the fungus : Phomopsis sp. CMU-LMA
2020
Online
Elektronische Ressource
Sch-642305 is an unusual bicyclic 10-membered macrolide produced by the filamentous fungus Phomopsis sp. CMU-LMA for which no biosynthetic evidence exists. Here, we generate a draft genome sequence of the producing organism and discover the biosynthetic gene cluster responsible for formation of Sch-642305. Targeted gene disruptions together with reconstitution of the pathway in the heterologous host Aspergillus oryzae dissect key chemical steps and shed light on a series of oxidoreductions occuring in the pathway. © The Royal Society of Chemistry.
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Investigating the biosynthesis of Sch-642305 in the fungus : Phomopsis sp. CMU-LMA
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Veröffentlichung: | 2020 |
Medientyp: | Elektronische Ressource |
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