Towards tissue engineering application for cleft defects
2023
Online
Elektronische Ressource
The main objective of this thesis was to investigate the current clinical practice and associated difficulties in treating cleft lip and palate, the state-of-the-art tissue engineering techniques for the reconstruction of oral clefts, and to assess the safety and efficacy of novel tissue engineering approaches for alveolar cleft defects. In Chapter 2, we compared the costs and complication rates of Secondary Alveolar Bone Grafting (SABG) outcomes in alveolar cleft patients treated either in daycare or with multiple day hospitalization (MDH). Daycare had marginally, but not substantially, higher rates of complications, the majority of which were classified by Clavien Dindo as Grade I (mild). According to the study, daycare after alveolar cleft surgery is about as safe as MDH, although much less expensive. In Chapter 3, we investigated intraoperative and early postoperative blood loss using the buccal fat pad (BFP) during cleft lip and/or cleft palate (CL/P) surgery that resulted in weight, and the procedure length can cause more blood loss during palatoplasty, which suggests that younger patients will have better results from their procedures. In Chapter 4, we conducted a systematic review and meta-analysis to assess the effectiveness of stem cell-based tissue engineering for the treatment of alveolar cleft (AC) and cleft palate (CP) deformities in animal models, which concluded that adding cells to biomaterials improves AC and CP reconstructions. In Chapter 5, a second systematic review and meta-analysis of controlled clinical trials utilizing regeneration materials for alveolar cleft repairs was carried out. The review also took the risk of bias (RoB) into account. According to the meta-analysis, the regenerative materials and iliac crest grafts did not differ significantly. Additionally, this review's findings indicated that control trials' high RoB indicated the need for quality improvement in control trials. In Chapter 6, we presented a clinical trial protocol t
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Towards tissue engineering application for cleft defects
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Veröffentlichung: | 2023 |
Medientyp: | Elektronische Ressource |
DOI: | 10.5463.thesis.404 |
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