Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection
2018
Online
Konferenz
Zugriff:
Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8+ T cells (TVM) are non-conventional T cells displaying memory properties that can be generated through responsiveness to interleukin (IL)-4. However, it is not clear if helminth-induced type 2 immunity functionally affects the TVM compartment. Here, we show that helminths expand CD44hiCD62LhiCXCR3hiCD49dlo TVM cells through direct IL-4 signaling in CD8+ T cells. Importantly, helminth-mediated conditioning of TVM cells provided enhanced control of acute respiratory infection with the murid gammaherpesvirus 4 (MuHV-4). This enhanced control of MuHV-4 infection could further be explained by an increase in antigen-specific CD8+ T cell effector responses in the lung and was directly dependent on IL-4 signaling. These results demonstrate that IL-4 during helminth infection can non-specifically condition CD8+ T cells, leading to a subsequently raised antigen-specific CD8+ T cell activation that enhanced control of viral infection.
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Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection
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Autor/in / Beteiligte Person: | Rolot, Marion ; Dougall, Annette ; Chetty, Alisha ; Javaux, Justine ; Chen, Ting ; Xiao, Xue ; Machiels, Bénédicte ; Selkirk, Murray ; Maizels, Rick ; Hokke, Cornelis ; Denis, Olivier ; Brombacher, Frank ; Vanderplasschen, Alain ; Gillet, Laurent ; Horsnell, William ; Dewals, Benjamin G |
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Veröffentlichung: | 2018 |
Medientyp: | Konferenz |
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