Enzymatic Debridement of Chronic Wounds : Preliminary Results
Morressier, 2017
Online
unknown
Objectives: Chronic and hard-to-heal wounds represent a major health burden, contributing to substantial disability, morbidity and cost (2-4% of the health care budget). Currently, non surgical means for wound bed preparation (WBP) used are slow and/or inefficient. There is an unmet need for a fast and effective WBP agent. We present the first proof of concept study assessing the efficacy and safety of NexoBridu00ae (NXB) in chronic/hard-to-heal wounds.Methods: A prospective, single arm, multicenter, preliminary study assessing the safety and efficacy of NXB in chronic, hard-to-heal wounds of different etiologies. Patients were treated with consecutive 4 hour applications of NXB until sufficient WBP for wound closure by surgical or not surgical means as judged by the investigators. Results: Twenty-four patients were included, suffering from wounds due to venous insufficiency (n=6), post traumatic necrosis (n=6), PVD (peripheral vascular disease) (n=4), diabetic foot ulcer (n=1), pressure sore (n=1), and necrosis post: surgery (n=3), lymphedema (n=2) and chronic steroid treatment (n=1). The gross NXB efficacy in all patients was 68% WBP in an average of 14 hours exposure (HE). WBP was found to be more effective in venous insufficiency (82% WBP, 17 HE), post traumatic necrosis (90% WBP, 7 HE), lymphedema (78%WBP, 22 HE), diabetic foot ulcer (95% WBP, 8 HE), pressure sore (95% WBP, 8 HE), and chronic steroid treatment patients (70% WBP, 12 HE). NXB was less effective in PVD with dry adherent eschar (< 30% WBP, 12 HE per patient) and post surgical dry adherent eschar (< 40% WBP, 21 HE).Conclusions: NXB enzymatic debridement was found to be effective in most etiologies of chronic wounds. Additional studies with larger numbers of patients in each etiology are needed in order to more accurately establish the clinical potential in chronic wounds.Funding: by MediWound Ltd.
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Enzymatic Debridement of Chronic Wounds : Preliminary Results
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Autor/in / Beteiligte Person: | Rosenberg, Lior |
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Veröffentlichung: | Morressier, 2017 |
Medientyp: | unknown |
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