Role of Arterial Pressure, Wall Stiffness, Pulse Pressure and Waveform in Arterial Wall Stress/Strain and Its Clinical Implications
2022., 2022
Online
unknown
Biomechanical stress applied to the intima of arteries has long been suspected as a factor in the initiation and localisation of atherosclerotic plaque, and it is implicated in the separation of plaque from the underlying arterial wall giving rise to the acute clinical consequences of thrombosis, dissection and embolism. The factors underlying transmural stress were investigated in-vitro using fresh porcine abdominal aortas on an experimental rig in which pulse pressure, pulse waveform, fluid viscosity, pulse rate, vessel wall compliance and systolic and diastolic blood pressure could be varied at will. Vessel wall compliance was progressively reduced by exposure of the artery to formaldehyde vapour for increased periods of time, a saline-treated artery being used as control. Centripetal transmural stress (CTS) and strain were studied by direct observation of the displacement of a compliant false intima (FI) using real-time B and M mode ultrasound, and by measuring the differential pressure between the space beneath the FI and the adjacent vessel lumen. CTS was found to be directly related to pulse pressure (r = 0.907, p 
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Role of Arterial Pressure, Wall Stiffness, Pulse Pressure and Waveform in Arterial Wall Stress/Strain and Its Clinical Implications
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Autor/in / Beteiligte Person: | Day, Thomas K. |
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Veröffentlichung: | 2022., 2022 |
Medientyp: | unknown |
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