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Several ursolic acid derivatives and pharmaceutical compositions thereof are provided. The ursolic acid derivatives and the pharmaceutical compositions thereof have at least one of an anticancer and an anti-inflammatory effects. A method for increasing a reactive oxygen species in a cell is also provided. The method comprises a step of providing the cell with a pharmaceutical composition including an ursolic acid derivative.

Titel:	URSOLIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF
Autor/in / Beteiligte Person:	Lin, Chun-Nan ; Tu, Huang-Yao ; Huang, A-Mei ; Wei, Bai-Luh ; Gan, Kim-Hong ; Hour, Tzyh-Chyuan ; Yang, Shyh-Chyun ; Pu, Yeong-Shiau ; Won, Shen-Jeu
Link:	View record in USPTO Patent Applications (Volltext)
Veröffentlichung:	2011
Medientyp:	Patent
Sonstiges:	Nachgewiesen in: USPTO Patent Applications Sprachen: English Document Number: 20110190388 Publication Date: August 4, 2011 Appl. No: 12/782395 Application Filed: May 18, 2010 Assignees: KAOHSIUNG MEDICAL UNIVERSITY (Kaohsiung City, TW) Claim: 1. An ursolic acid derivative having a structure being one selected from a group consisting of [chemical expression included] wherein R is one selected from a group consisting of a C5-C12 alkyl group, CH(CH3)2, [chemical expression included] an alcohol group and CH2COOC(CH3)3. Claim: 2. The ursolic acid derivative as claimed in claim 1, wherein the C5-C12 alkyl group is one of CH2CH2CH2CH2CH3 and CH2CH2CH2CH2CH2CH3. Claim: 3. The ursolic acid derivative as claimed in claim 1, wherein the alcohol group is CH2CH2OH. Claim: 4. The ursolic acid derivative as claimed in claim 1, having at least one of an anticancer and an anti-inflammatory activities. Claim: 5. A pharmaceutical composition comprising the ursolic acid derivative as claimed in claim 1. Claim: 6. The pharmaceutical composition as claimed in claim 5, further comprising a pharmaceutically acceptable carrier. Claim: 7. The pharmaceutical composition as claimed in claim 5, having at least one of an anticancer and an anti-inflammatory effects. Claim: 8. The pharmaceutical composition as claimed in claim 5, further comprising a drug having an anticancer activity. Claim: 9. The pharmaceutical composition as claimed in claim 8, wherein the ursolic acid derivative enhances the anticancer activity of the drug. Claim: 10. A method for inducing at least one of an anticancer and an anti-inflammatory effects, comprising a step of administering to a subject in need thereof an effective amount of the pharmaceutical composition as claimed in claim 5. Claim: 11. The method as claimed in claim 10, further comprising a step of administering to the subject an effective amount of a drug having an anticancer activity. Claim: 12. The method as claimed in claim 11, wherein the pharmaceutical composition enhances the anticancer activity of the drug. Claim: 13. The method as claimed in claim 10, wherein the pharmaceutical composition further includes a pharmaceutically acceptable carrier. Claim: 14. A method for increasing a reactive oxygen species (ROS) in a cell, comprising a step of: providing the cell with a pharmaceutical composition including an ursolic acid derivative. Claim: 15. The method as claimed in claim 14, wherein the pharmaceutical composition further includes a pharmaceutically acceptable carrier. Claim: 16. The method as claimed in claim 14, wherein the ursolic acid derivative has a structure being one selected from a group consisting of [chemical expression included] wherein R is one selected from a group consisting of a C5-C12 alkyl group, CH(CH3)2 [chemical expression included] an alcohol group and CH2COOC(CH3)3. Claim: 17. The method as claimed in claim 16, wherein the C5-C12 alkyl group is one of CH2CH2CH2CH2CH3 and CH2CH2CH2CH2CH2CH3. Claim: 18. The method as claimed in claim 16, wherein the alcohol group is CH2CH2OH. Claim: 19. The method as claimed in claim 16, wherein the cell is a tumor cell. Current U.S. Class: 514/450 Current International Class: 61; 07; 61; 61; 61; 07; 61; 07; 07; 07; 07; 12

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URSOLIC ACID DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF