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- Nachgewiesen in: USPTO Patent Applications
- Sprachen: English
- Document Number: 20110207806
- Publication Date: August 25, 2011
- Appl. No: 13/028853
- Application Filed: February 16, 2011
- Assignees: Unigen, Inc. (Lacey, WA, US)
- Claim: 1. A method for preventing or treating cyclooxygenase (COX) and lipoxygenase (LOX) mediated diseases or conditions of the skin, the method comprising administering to a host in need thereof an effective amount of a composition comprising a mixture of at least one Free-B-ring flavonoid and at least one flavan.
- Claim: 2. The method of claim 1 wherein the ratio of the at least one Free-B-Ring flavonoid to the at least one flavan in the composition is ranges from 99:1 Free-B-Ring flavonoid:flavan to 1:99 of Free-B-Ring flavonoid:flavan.
- Claim: 3. The method of claim 2 wherein the ratio of at least one Free-B-Ring flavonoid:the at least one flavan in the composition is 20:80.
- Claim: 4. The method of claim 1 wherein the at least one Free-B-Ring flavonoid has the following structure: wherein [chemical expression included] R1, R2, R3, R4, and R5 are independently —OH, —SH, —OR, —SR, —NH2, —NHR, —NR2, —NR3+X−, a carbon, oxygen, nitrogen or sulfur, glycoside of a single or a combination of multiple sugars, wherein the sugars comprise aldopentoses, methyl-aldopentose, aldohexoses, ketohexose and-or their chemical derivatives thereof; wherein R is an alkyl group having between 1-10 carbon atoms; and X is hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride or carbonate.
- Claim: 5. The method of claim 1 wherein the at least one flavan has the following structure: [chemical expression included] wherein R1, R2, R3, R4 and R5 are independently H, —OH, —SH, —OCH3, —SCH3, —OR, —SR, —NH2, —NRH, —NR2, —NR3+X−, a gallate ester, an acetate ester, a cinnamoylester, a hydroxyl-cinnamoyl esters, a trihydroxybenzoyl esters, a caffeoyl esters, a carbon, oxygen, nitrogen or sulfur glycoside of a single, or a combination of multiple sugars, wherein the sugars comprise, aldopentoses, methyl aldopentose, aldohexoses, ketohexose or thereof or dimer, trimer or other polymerized flavans; wherein R is an alkyl group having between 1-10 carbon atoms; and X is hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride or carbonate.
- Claim: 6. The method of claim 1 wherein the at least one Free-B-Ring flavonoid and the at least one flavan are obtained by organic synthesis or are isolated from a plant.
- Claim: 7. The method of claim 6 wherein the at least one Free-B-Ring flavonoid and the at least one flavan are isolated from a plant part, wherein the plant part is stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers or other reproductive organs or leaves or other aerial parts.
- Claim: 8. The method of claim 6 wherein the at least one Free-B-Ring flavonoid is isolated from a Annonaceae, Asteraceae, Bignoniaceae, Combretaceae, Compositae, Euphorbiaceae, Labiatae, Lauranceae, Leguminosae, Moraceae, Pinaceae, Pteridaceae, Sinopteridaceae, Ulmaceae or Zingiberacea plant family.
- Claim: 9. The method of claim 6 wherein the at least one Free-B-Ring flavonoid is isolated from a Desmos, Achyrocline, Oroxylum, Buchenavia, Anaphalis, Cotula, Gnaphalium, Helichrysum, Centaurea, Eupatorium, Baccharis, Sapium, Scutellaria, Molsa, Colebrookea, Stachys, Origanum, Ziziphora, Lindera, Actinodaphne, Acacia, Derris, Glycyrrhiza, Millettia, Pongamia, Tephrosia, Artocarpus, Ficus, Pityrogramma, Notholaena, Pinus, Ulmus or Alpinia plant genus.
- Claim: 10. The method claim 6 wherein the at least one flavan is isolated from a Acacia catechu, Acacia concinna, Acacia farnesiana, Acacia Senegal, Acacia speciosa, Acacia arabica, A. caesia, A. pennata, A. sinuata. A. mearnsii, A. picnantha, A. dealbata, A. auriculiformis, A. holoserecia and A. mangium plant species.
- Claim: 11. The method of claim 6 wherein the at least one Free-B-ring flavonoid is isolated from a plant or plants in the Scutellaria genus of plants and the at least one flavan is isolated from a plant or plants in the Acacia genus of plants.
- Claim: 12. The method of claim 1 wherein the composition is administered in a dosage ranging from 0.001 to 200 mg/kg of body weight of the host.
- Claim: 13. The method of claim 1 wherein the composition is administered in a pharmaceutical, dermatological or cosmetic formulation comprising from 0.001 weight percent (wt %) to 40.0 wt % of the mixture of Free-B-Ring flavonoids and flavans in a pharmaceutically, dermatologically or cosmetically acceptable carrier.
- Claim: 14. The method of claim 1 wherein the composition is administered by topical, aerosol, suppository, intradermic, intramusclar or intravenous administration.
- Claim: 15. The method of claim 14 wherein the administration is topical.
- Claim: 16. The method of claim 15 wherein the composition is administered using a nonsticking gauze, a bandage, a swab, a cloth wipe, a patch, a mask, a protectant, a cleanser, an antiseptic, a solution, a cream, a lotion, an ointment, a gel or an emulsion, a liquid, a paste, a soap, or a powder.
- Claim: 17. The method of claim 1 wherein the pharmaceutical composition further comprises a conventional excipient that is pharmaceutically, dermatologically or cosmetically suitable for topical application and optionally an adjuvant, and/or a carrier, and/or a regular or controlled releasing vehicle.
- Claim: 18. The method of claim 1 wherein the COX and LOX mediated diseases or conditions of the skin are sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial or viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma or other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind or dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin.
- Claim: 19-33. (canceled)
- Claim: 34. A method for simultaneously inhibiting the enzymatic activity of the COX and LOX enzymes in the skin, the method comprising administering to a host in need thereof an effective amount of a pharmaceutical composition comprising a mixture of at least one Free-B-Ring flavonoids and at least one flavan.
- Claim: 35. The method of claim 34 wherein the pharmaceutical composition is administered in a pharmaceutical, dermatological or cosmetic formulation comprising from 0.001 weight percent (wt %) to 40.0 wt % of the mixture of at least one Free-B-Ring flavonoids and at least one flavans in a pharmaceutically, dermatologically or cosmetically acceptable carrier.
- Claim: 36. The method of claim 34 wherein the composition is administered by topical, aerosol, suppository, intradermic, intramusclar or intravenous administration.
- Claim: 37. The method of claim 36 wherein administration is topical.
- Claim: 38. The method of claim 34 wherein the pharmaceutical composition is administered using a nonsticking gauze, a bandage, a swab, a cloth wipe, a patch, a mask, a protectant, a cleanser, an antiseptic, a solution, a cream, a lotion, an ointment, a gel or an emulsion, a liquid, a paste, a soap, or a powder.
- Claim: 39. The method of claim 34 wherein the pharmaceutical composition further comprises a conventional excipient that is pharmaceutically, dermatologically and cosmetically suitable for topical application and optionally an adjuvant, and/or a carrier, and/or a regular or controlled releasing vehicle.
- Claim: 40-45. (canceled)
- Claim: 46. The method of claim 1, wherein the composition is administered orally.
- Claim: 47. A method for preventing or treating diseases or conditions of the skin, the method comprising administering to a host in need thereof an effective amount of a composition comprising a mixture of at least one Free-B-ring flavonoid and at least one flavan, wherein the diseases or conditions of the skin are sun burns, thermal burns, acne, topical wounds, minor inflammatory conditions caused by fungal, microbial or viral infections, vitilago, systemic lupus erythromatosus, psoriasis, carcinoma, melanoma or other mammal skin cancers, skin damage resulting from exposure to ultraviolet (UV) radiation, chemicals, heat, wind or dry environments, wrinkles, saggy skin, lines and dark circles around the eyes, dermatitis and other allergy related conditions of the skin or sensitive skin.
- Claim: 48. The method of claim 47 wherein the ratio of the at least one Free-B-Ring flavonoid:the at least one flavan in the composition of matter is about 20:80.
- Claim: 49. The method of claim 47 wherein the at least one Free-B-Ring flavonoid has the following structure: [chemical expression included] wherein R1, R2, R3, R4, and R5 are independently —H, —OH, —SH, —OR, —SR, —NH2, —NHR, —NR2, —NR3+X−, a carbon, oxygen, nitrogen or sulfur, glycoside of a single or a combination of multiple sugars, wherein the sugars comprise aldopentoses, methyl-aldopentose, aldohexoses, ketohexose or derivatives thereof; wherein R is an alkyl group having between 1-10 carbon atoms; and X is hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride or carbonate.
- Claim: 50. The method of claim 47 wherein the at least one flavan has the following structure: [chemical expression included] wherein R1, R2, R3, R4 and R5 are independently H, —OH, —SH, —OCH3, —SCH3, —OR, —SR, —NH2, —NRH, —NR2, —NR3+X−, a gallate ester, an acetate ester, a cinnamoylester, a hydroxyl-cinnamoyl ester, a trihydroxybenzoyl ester, a caffeoyl ester, a carbon, oxygen, nitrogen or sulfur glycoside of a single, or a combination of multiple sugars, wherein the sugars comprise, aldopentoses, methyl aldopentose, aldohexoses, ketohexose or derivatives thereof or dimer, trimer or other polymerized flavans; wherein R is an alkyl group having between 1-10 carbon atoms; and X is hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride or carbonate.
- Claim: 51. The method of claim 47, wherein the disease or condition of the skin is skin damage resulting from exposure to ultraviolet (UV) radiation.
- Claim: 52. The method of claim 47, wherein the composition is administered topically.
- Claim: 53. The method of claim 47, wherein the composition is administered orally.
- Claim: 54. A method for improving skin appearance, the method comprising administering to a host in need thereof an effective amount of a composition comprising a mixture of at least one Free-B-ring flavonoid and at least one flavan.
- Claim: 55. The method of claim 54 wherein the ratio of the at least one Free-B-Ring flavonoid:the at least one flavan in the composition of matter is about 20:80.
- Claim: 56. The method of claim 54 wherein the at least one Free-B-Ring flavonoid has the following structure: [chemical expression included] wherein R1, R2, R3, R4, and R5 are independently —H, —OH, —SH, —OR, —SR, —NH2, —NHR, —NR2, —NR3+X−, a carbon, oxygen, nitrogen or sulfur, glycoside of a single or a combination of multiple sugars, wherein the sugars comprise aldopentoses, methyl-aldopentose, aldohexoses, ketohexose or derivatives thereof; wherein R is an alkyl group having between 1-10 carbon atoms; and X is hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride or carbonate.
- Claim: 57. The method of claim 54 wherein the at least one flavan has the following structure: [chemical expression included] wherein R1, R2, R3, R4 and R5 are independently H, —OH, —SH, —OCH3, —SCH3, —OR, —SR, —NH2, —NRH, —NR2, —NR3+X−, a gallate ester, an acetate ester, a cinnamoylester, a hydroxyl-cinnamoyl ester, a trihydroxybenzoyl ester, a caffeoyl ester, a carbon, oxygen, nitrogen or sulfur glycoside of a single, or a combination of multiple sugars, wherein the sugars comprise aldopentoses, methyl aldopentose, aldohexoses, ketohexose or derivatives thereof or dimer, trimer or other polymerized flavans; wherein R is an alkyl group having between 1-10 carbon atoms; and X is hydroxyl, chloride, iodide, sulfate, phosphate, acetate, fluoride or carbonate.
- Claim: 58. The method of claim 54, wherein the method provides smooth and youthful skin with improved elasticity, reduces and delays aging, enhances youthful appearance, enhances texture, increases flexibility, increases firmness, increases smoothness or increases suppleness of the skin.
- Claim: 59. The method of claim 54, wherein the method enhances youthful appearance of the skin.
- Claim: 60. The method of claim 54, wherein the composition is administered topically.
- Claim: 61. The method of claim 54, wherein the composition is administered orally.
- Current U.S. Class: 514/456
- Current International Class: 61; 61; 61; 61
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