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- Nachgewiesen in: USPTO Patent Applications
- Sprachen: English
- Document Number: 20240033365
- Publication Date: February 1, 2024
- Appl. No: 18/224879
- Application Filed: July 21, 2023
- Assignees: University of South Alabama (Mobile, AL, US)
- Claim: 1. A compound of Formula (I): [chemical expression included] or a stereoisomer or pharmaceutically acceptable salt thereof, wherein, o is an integer from 1 to 50; p is an integer from 1 to 20; Q is a polyoxazoline polymer; R is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted heterocyclylalkyl; and X is an amino acid chain between 1-50 amino acids in length wherein at least one of the amino acids is a hydroxyl-containing amino acid.
- Claim: 2. The compound of claim 1, wherein Q is [chemical expression included] and m is an integer from 190 to 950.
- Claim: 3. The compound of claim 2, wherein Q is [chemical expression included] and m is an integer from 190 to 950.
- Claim: 4. The compound of claim 1, wherein: m is an integer from 190 to 350; o is an integer from 1 to 10; p is an integer from 1 to 10; and R is hydrogen, alkyl, or substituted alkyl.
- Claim: 5. The compound of claim 1, wherein X is 1-11 amino acids in length.
- Claim: 6. The compound of claim 1, wherein X is 1-5 amino acids in length.
- Claim: 7. The compound of claim 1, wherein X is 1-3 amino acids in length.
- Claim: 8. The compound of claim 7, wherein X is selected from the group comprising of: Tyr, Tyr-Phe, Phe-Tyr, Tyr-Phe-Phe, Phe-Phe-Tyr, Phe-Tyr-Phe, Ser, Ser-Phe, Phe-Ser, Ser-Phe-Phe, Phe-Phe-Ser, Phe-Ser-Phe, Thr, Thr-Phe, Phe-Thr, Thr-Phe-Phe, Phe-Phe-Thr, Phe-Thr-Phe, and Tyr-Tyr-Tyr.
- Claim: 9. The compound of claim 8, wherein X is Tyr-Phe, Phe-Tyr, or Tyr-Tyr.
- Claim: 10. The compound of claim 8, wherein X is Tyr-Tyr-Tyr.
- Claim: 11. The compound of claim 1, which is [chemical expression included] wherein m is an integer from 5 to 20; o is an integer from 1 to 4; p is an integer from 1 to 5; and R is methyl, [chemical expression included] wherein m is an integer from 5 to 20; o is an integer from 1 to 4; p is an integer from 1 to 5; and R is methyl, [chemical expression included] wherein m is an integer from 5 to 20; o is an integer from 1 to 4; p is an integer from 1 to 5; and R is methyl, or [chemical expression included] wherein m is an integer from 5 to 20; o is an integer from 1 to 4; p is an integer from 1 to 5; and R is methyl.
- Claim: 12. A pharmaceutical composition, comprising a therapeutically effective amount of the compound or pharmaceutically acceptable salt or stereoisomer thereof of claim 1, and a pharmaceutically acceptable carrier.
- Claim: 13. The pharmaceutical composition of claim 12, which is in the form of an inhalant and the carrier comprises a propellant.
- Claim: 14. The pharmaceutical composition of claim 12, which is in the form of an injectable formulation.
- Claim: 15. The pharmaceutical composition of claim 14, wherein the carrier comprises an aqueous vehicle.
- Claim: 16. The pharmaceutical composition of claim 12, which is in the form of a topical formulation.
- Claim: 17. The pharmaceutical composition of claim 16, wherein the topical formulation is a cream, ointment, gel, or foam.
- Claim: 18. The pharmaceutical composition of claim 16, further comprising a non-steroidal anti-inflammatory drug (NSAID).
- Claim: 19. The pharmaceutical composition of claim 16, further comprising an analgesic excipient.
- Claim: 20. A method of treating a disease or disorder mediated by Formyl Peptide Receptor 1 or 2, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): [chemical expression included] or a stereoisomer or pharmaceutically acceptable salt thereof, wherein, o is an integer from 1 to 50; p is an integer from 1 to 20; Q is a polyoxazoline polymer; R is hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted aralkyl, or unsubstituted or substituted heterocyclylalkyl; and X is an amino acid chain between 1-50 amino acids in length wherein at least one of the amino acids is a hydroxyl-containing amino acid.
- Claim: 21. The method of claim 20, wherein the disease or disorder is an inflammatory disease or disorder.
- Claim: 22. The method of claim 21, wherein the inflammatory disease or order is characterized by mucosal inflammation, or wherein the inflammatory disease or disorder is a respiratory disease or disorder, asthma, chronic obstructive pulmonary disease (COPD), eczema, acute lung injury, arthritis, psoriasis, or an intestinal inflammatory disease or disorder.
- Claim: 23. The method of claim 22, wherein the intestinal inflammatory disease or disorder is colitis.
- Claim: 24. The method of claim 20, wherein the disease or disorder is a hyper-IgE syndrome (HIES).
- Claim: 25. The method of claim 24, wherein the HIES is autosomal dominant hyper-IgE syndrome (AD-HIES).
- Claim: 26. The method of claim 20, wherein Q is [chemical expression included] wherein m is an integer from 190 to 950.
- Claim: 27. The method of claim 26, wherein Q is [chemical expression included] wherein m is an integer from 190 to 950.
- Claim: 28. The method of claim 20, wherein: m is an integer from 190 to 350; o is an integer from 1 to 10; p is an integer from 1 to 10; and R is hydrogen, alkyl, or substituted alkyl.
- Claim: 29. The method of claim 20, wherein X is 1-11 amino acids in length.
- Claim: 30. The method of claim 20, wherein X is 1-5 amino acids in length.
- Claim: 31. The method of claim 20, wherein X is 1-3 amino acids in length.
- Claim: 32. The method of claim 31, wherein X is selected from the group comprising of: Tyr, Tyr-Phe, Phe-Tyr, Tyr-Phe-Phe, Phe-Phe-Tyr, Phe-Tyr-Phe, Ser, Ser-Phe, Phe-Ser, Ser-Phe-Phe, Phe-Phe-Ser, Phe-Ser-Phe, Thr, Thr-Phe, Phe-Thr, Thr-Phe-Phe, Phe-Phe-Thr, Phe-Thr-Phe, and Tyr-Tyr-Tyr.
- Claim: 33. The method of claim 32, wherein X is Tyr-Phe, Phe-Tyr or Tyr-Tyr.
- Claim: 34. The method of claim 32, wherein X is Tyr-Tyr-Tyr.
- Claim: 35. The method of claim 20, wherein the compound is [chemical expression included] wherein m is an integer from 5 to 20; o is an integer from 1 to 4; p is an integer from 1 to 5; and R is methyl, [chemical expression included] wherein m is an integer from 5 to 20; o is an integer from 1 to 4; p is an integer from 1 to 5; and R is methyl, [chemical expression included] wherein m is an integer from 5 to 20; o is an integer from 1 to 4; p is an integer from 1 to 5; and R is methyl, or [chemical expression included] wherein m is an integer from 5 to 20; o is an integer from 1 to 4; p is an integer from 1 to 5; and R is methyl.
- Current International Class: 61; 61
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