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Dipterinyl calcium pentahydrate (DCP) and therapeutic methods based thereon

Moheno, Phillip ; Pfleiderer, Wolfgang
2010
Online Patent

Titel:
Dipterinyl calcium pentahydrate (DCP) and therapeutic methods based thereon
Autor/in / Beteiligte Person: Moheno, Phillip ; Pfleiderer, Wolfgang
Link:
Veröffentlichung: 2010
Medientyp: Patent
Sonstiges:
  • Nachgewiesen in: USPTO Patent Grants
  • Sprachen: English
  • Patent Number: 7,662,820
  • Publication Date: February 16, 2010
  • Appl. No: 11/981398
  • Application Filed: October 30, 2007
  • Assignees: SanRX Pharmaceuticals, Inc. (La Jolla, CA, US)
  • Claim: 1. The compound dipterinyl calcium pentahydrate (DCP).
  • Claim: 2. A method of synthesizing dipterinyl calcium pentahydrate (DCP) comprising: dissolving pterin in an aqueous solution of NaOH, adding CaCl 2 .2H 2 O to the solution with stirring at a pH of about 11, continuing stirring for about 1 day, and collecting the precipitate as DCP.
  • Claim: 3. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and the compound dipterinyl calcium pentahydrate (DCP).
  • Current U.S. Class: 514/249
  • Patent References Cited: 6358953 March 2002 Moheno ; 6844343 January 2005 Pfleiderer et al.
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Chem. 34(12):3367-3370 (1995). cited by other ; PCT/US07/23012 Search Report dated Jun. 17, 2008. cited by other ; Moheno, P., et al., “Plasma Cytokine Changes Induced by the Antitumor Agents Dipterinyl Calcium Pentahydrate (DCP) and Related Calcium Pterins,” Immunology, article in press, received Apr. 2, 2008. cited by other ; Moheno, P., et al., “Plasma Cytokine Changes Induced by the Antitumor Agents Dipterinyl Calcium Pentahydrate (DCP) and Related Calcium Pterins,” Pteridines 19 (2):49 (2008). cited by other ; Moheno, P., et al., “Cytokine and IDO Metabolite Changes Effected by Calcium Pterin During Inhibition of MDA-MB-231 Xenograph Tumors in Nude Mice,” International Journal of Pharmaceutics 355:238-248 (2008). cited by other ; Moheno, P., et al., “Mechanism of Action Studies with the Antitumor Agent Calcium-Pterin,” Pteridines 18(2):50 (2007). cited by other ; Moheno, P., et al., “Role of Calcium Pterin in Natural Killer (NK) Cell Activation and Indoleamine 2,3-Dioxygenase (IDO) Modulation for Antitumor Activity,” Pteridines 16:140 (2005). cited by other ; Moheno, P., et al., “Calcium Pterin as an Antitumor Agent,” International Journal of Pharmaceutics 271:293-300 (2004). cited by other ; Winkler, C., et al., “Calcium-Pterin Suppresses Mitogen-Induced Tryptophan Degradation and Neopterin Production in Peripheral Blood Mononuclear Cells,” Immunobiology 211:779-784 (2006). cited by other ; Stea, B., et al., “Folate and Pterin Metabolism by Cancer Cells in Culture,” Cancer Research 38:2378-2384 (1978). cited by other
  • Assistant Examiner: Jaisle, Cecilia M
  • Primary Examiner: Berch, Mark L
  • Attorney, Agent or Firm: Wilson Sonsini Goodrich & Rosati

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