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- Nachgewiesen in: USPTO Patent Grants
- Sprachen: English
- Patent Number: 8,802,707
- Publication Date: August 12, 2014
- Appl. No: 11/309355
- Application Filed: July 31, 2006
- Claim: 1. A method for reducing risk of an inflammatory-induced disease caused by intra-phagocytic prokaryotic pathogens, wherein the inflammatory-induced disease is selected from the group consisting of Bladder Cancer, Breast Cancer, Colorectal Cancer, Gastric Cancer, Liver Cancer, Lung Cancer, Pancreatic Cancer, Prostate Cancer, and Thyroid Cancer; comprising administering to a subject in need thereof a therapeutically effective amount of Olmesartan or Olmesartan medoxomil, together with one or more antibiotics capable of inhibiting bacterial protein synthesis by inhibiting the intra-phagocytic prokaryotic 70S-bacterial-ribosome to treat intra-phagocytic prokaryotic pathogens and reduce the risk of an inflammatory-induced disease, wherein the Olmesartan or Olmesartan medoxomil is administered by semi-continuous or intermittent administration in such a way that the Olmesartan or Olmesartan medoxomil has a concentration in the subject's bloodstream that is constrained from falling below 30% of its peak value.
- Claim: 2. The method defined in claim 1 wherein the Olmesartan or Olmesartan medoxomil is administered by using a method of semi-continuous administration selected from the group consisting of trans-cutaneous-patch, implanted infusion device, implanted drug delivery system, external infusion device, trans-cutaneous delivery system, and continuous IntraVenous infusion.
- Claim: 3. The method defined in claim 1 wherein the Olmesartan or Olmesartan medoxomil is administered by using a method of intermittent administration selected from the group consisting of oral dosing at intervals sufficiently small to stabilize the ARB level in the subject's bloodstream between 30% and 100% of its peak value, injections at intervals sufficiently small to stabilize the ARB in the subject's bloodstream level between 30% and 100% of its peak value, intermittent IntraVenous (IV) at intervals sufficiently small to stabilize the ARB level in the subject's bloodstream between 30% and 100% of its peak value, and trans-cutaneous infusion at intervals sufficiently small to stabilize the ARB level in the subject's bloodstream between30% and 100% of its peak value.
- Claim: 4. The method defined in claim 1 wherein the Olmesartan or Olmesartan medoxomil is administered using a technique designed to slow the release, or to slow the absorption, of the Olmesartan or Olmesartan medoxomil and thus stabilize its level in the subject's bloodstream at between 40% and 100%, where such technique is selected from the group consisting of formulation with polymers, substances known as sustained-release binders, and other semi-soluble compounds.
- Claim: 5. The method defined in claim 1 wherein the antibiotic is a 30S Bacterial Ribosomal subunit inhibitor selected from the group consisting of Minocycline, Minocycline hydrochloride, Demeclocycline, Demeclocycline hydrochloride, Tigecycline, Tetracycline, Oxytetracycline, Doxycycline, Doxycycline hyclate, Spectinomycin, Hygromycin, Paromomycin, Streptomycin, Kanamycin, Gentamicin, Tobramycin, Amikacin, Netilmicin, and Neomycin.
- Claim: 6. The method defined in claim 1 wherein the antibiotic is a 30S Bacterial Ribosomal subunit inhibitor selected from the group consisting of The Tetracycline family of antibiotics.
- Claim: 7. The method defined in claim 6 wherein the 30S Bacterial Ribosomal subunit inhibitor antibiotic is administered with a pulsatile dosing frequency between once every 36 hours and once every 8 days, such that the concentration of the antibiotic in plasma is allowed to drop below the minimum inhibitory concentration before the next dose of antibiotic is administered.
- Claim: 8. The method defined in claim 1 wherein the antibiotic is a 50S Bacterial Ribosomal subunit inhibitor selected from the group consisting of Azithromycin, Clarithromycin, Chloramphenicol, Linezolid, Erythromycin, Roxithromycin, Troleandomycin, Tylocin, Carbomycin A, Clindamycin, Lincomycin, Cethromycin, Telithromycin, Sparsomycin, Tiamulin, Dalfopristin, and Quinupristin.
- Claim: 9. The method defined in claim 8 wherein the 50S Bacterial Ribosomal subunit inhibitor antibiotic is administered with a pulsatile dosing frequency between once every 36 hours and once every 21 days, such that the concentration of the antibiotic in plasma is allowed to drop below the minimum inhibitory concentration before the next dose of antibiotic is administered.
- Claim: 10. The method defined in claim 1 wherein the 70S bacterial-ribosome is inhibited by two or more antibiotics selected so that both the 30S and50S subunits are symbiotically inhibited from full bacterial protein synthesis.
- Claim: 11. The method defined in claim 10 wherein the 70S ribosome is inhibited by one 30S subunit inhibiting antibiotic selected from the group consisting of Minocycline, Minocycline hydrochloride, Demeclocycline, Demeclocycline hydrochloride, Tigecycline, Tetracycline, Oxytetracycline, Doxycycline, Doxycycline hyclate, Spectinomycin, Hygromycin, Paromomycin, Streptomycin, Kanamycin, Gentamicin, Tobramycin, Amikacin, Netilmicin, and Neomycin; together with one or more 50S subunit inhibiting antibiotics selected from the group consisting of Azithromycin, Clarithromycin, Clindamycin, Chloramphenicol, Linezolid, Erythromycin, Roxithromycin, Troleandomycin, Tylocin, Carbomycin A, Sparsomycin, Lincomycin, Cethromycin, Telithromycin, Tiamulin, Dalfopristin, and Quinupristin.
- Claim: 12. The method defined in claim 11 wherein some, or all, of the antibiotics are administered with a pulsatile dosing frequency between once every 36 hours and once every 21 days, so that the concentration of the antibiotic in plasma is allowed to drop below the minimum inhibitory concentration before the next dose of antibiotic is administered.
- Claim: 13. The method defined in claim 1 wherein the one or more 70S bacterial-ribosome-inhibiting antibiotics comprise one 30S ribosomal sub-unit inhibiting antibiotic selected from the group consisting of Minocycline, Minocycline hydrochloride, Demeclocycline, and Demeclocycline hydrochloride; together with Azithromycin 50S subunit inhibiting antibiotic; wherein the 30S ribosomal sub-unit inhibitor is administered at a frequency between 36 hours and 8 days; and wherein the Azithromycin is administered at a frequency between 6 days and 21 days.
- Claim: 14. The method defined in claim 1 wherein the one or more 70S bacterial-ribosome-inhibiting antibiotics comprise one selected from the group consisting of inhibitors of the 30S ribosomal sub-unit Minocycline, Minocycline hydrochloride, Demeclocycline, Demeclocycline hydrochloride, Tigecycline, Tetracycline, Oxytetracycline, Doxycycline, Doxycycline hyclate, Spectinomycin, Hygromycin, Paromomycin, Streptomycin, Kanamycin, Gentamicin, Tobramycin, Amikacin, Netilmicin and Neomycin; together with one selected from the group consisting of the 50S subunit inhibiting antibiotics which bind near the PTC Clindamycin, Dalfopristin, Chloramphenicol, Linezolid, Tiamulin, and Lincomycin.
- Claim: 15. The method defined in claim 1 wherein the one or more 70S bacterial-ribosome-inhibiting antibiotics comprise one antibiotic from the group consisting of the 30S subunit inhibitors Minocycline, Minocycline hydrochloride, Demeclocycline, Demeclocycline hydrochloride, Tigecycline, Tetracycline, Oxytetracycline, Doxycycline, Doxycycline hyclate, Spectinomycin, Hygromycin, Paromomycin, Streptomycin, Kanamycin, Gentamicin, Tobramycin, Amikacin, Netilmicin and Neomycin; together with an antibiotic from the group consisting of the 50S subunit inhibitors Azithromycin, Clarithromycin, Erythromycin, Roxithromycin, Troleandomycin, Tylocin, Carbomycin A, Sparsomycin, Lincomycin, Cethromycin, Telithromycin, and Quinupristin; together with one selected from the group consisting of the 50S subunit inhibiting antibiotics which bind near the PTC Clindamycin, Dalfopristin, Chloramphenicol, Linezolid, Tiamulin, and Lincomycin.
- Claim: 16. The method defined in claim 1 wherein the one or more 70S bacterial-ribosome-inhibiting antibiotics comprise one antibiotic from the group consisting of the 30S subunit inhibitors Minocycline, Minocycline hydrochloride, Demeclocycline, Demeclocycline hydrochloride, Tigecycline, Tetracycline, Oxytetracycline, Doxycycline, Doxycycline hyclate, Spectinomycin, Hygromycin, Paromomycin, Streptomycin, Kanamycin, Gentamicin, Tobramycin, Amikacin, Netilmicin and Neomycin; together with two symbiotic 50S subunit inhibiting antibiotics Azithromycin and Clindamycin; wherein the 30S subunit inhibitor is administered at a frequency between 36 and 8 days; wherein the Azithromycin is administered at a frequency between 6 and 21 days; and wherein the Clindamycin is administered at a frequency between 36 hours and 21 days.
- Claim: 17. The method defined in claim 1 wherein two 70S bacterial-ribosome-inhibiting antibiotics are selected, one from the group consisting of the 50S subunit inhibitors Azithromycin, Clarithromycin, Erythromycin, Roxithromycin, Troleandomycin, Tylocin, Carbomycin A, Sparsomycin, Lincomycin, Cethromycin, Telithromycin, and Quinupristin; together with one selected from the group consisting of the 50S subunit inhibiting antibiotics which bind near the PTC Clindamycin, Dalfopristin, Chloramphenicol, Linezolid, Tiamulin, and Lincomycin.
- Claim: 18. The method defined in claim 1 wherein 40 mg of Olmesartan Medoxomil is administered every 6 hours, 100 mg of Minocycline hydrochloride is administered every 48 hours, and 125 mg of Azithromycin is administered every 10 days.
- Claim: 19. The method defined in claim 18 , further wherein 150 mg of Clindamycin is administered every 48 hours.
- Current U.S. Class: 514/382
- Patent References Cited: 5563130 October 1996 Backer et al. ; 2003/0083339 May 2003 Tamura ; 2003/0181406 September 2003 Schetter et al. ; 2003/0199424 October 2003 Smith et al. ; 2003/0207819 November 2003 Moskowitz ; 2004/0097565 May 2004 Terashita et al. ; 2004/0219208 November 2004 Kawamura et al. ; 2005/0112638 May 2005 Sandberg ; 2005/0119323 June 2005 Kubota et al. ; 2006/0025358 February 2006 Marshall ; 2006/0135422 June 2006 Moskowitz ; 2007/0135504 June 2007 Marshall
- Other References:
- Assistant Examiner: Deck, Jason A
- Primary Examiner: Carter, Kendra D
- Attorney, Agent or Firm: Morrison & Foerster LLP
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