Fusion protein comprising growth differentiation factor 11 and epidermal growth factor with enhanced anti-oxidation activity and enhanced skin cell proliferation effect and cosmetic composition for anti-wrinkle comprising the same as effective component

NEXGEN BIOTECHNOLOGIES, INC. ; Lee, Sun Kyo

2024

Online Patent

Zugriff:

View record in USPTO Patent Grants (Volltext)

A fusion protein according to an embodiment of the present disclosure includes a growth differentiation factor 11 and an epidermal growth factor with an enhanced anti-oxidation activity and an enhanced skin cell proliferation effect, A cosmetic composition according to an embodiment of the present disclosure includes the fusion protein as an effective component. The cosmetic composition can be advantageously used in future as a material of a functional cosmetic product.

Titel:	Fusion protein comprising growth differentiation factor 11 and epidermal growth factor with enhanced anti-oxidation activity and enhanced skin cell proliferation effect and cosmetic composition for anti-wrinkle comprising the same as effective component
Autor/in / Beteiligte Person:	NEXGEN BIOTECHNOLOGIES, INC. ; Lee, Sun Kyo
Link:	View record in USPTO Patent Grants (Volltext)
Veröffentlichung:	2024
Medientyp:	Patent
Sonstiges:	Nachgewiesen in: USPTO Patent Grants Sprachen: English Patent Number: 11986,545 Publication Date: May 21, 2024 Appl. No: 17/599061 Application Filed: June 01, 2017 Assignees: NEXGEN BIOTECHNOLOGIES, INC. (Seoul, KR), Lee, Sun Kyo (Gyeonggi-Do, KR) Claim: 1. A fusion protein having the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4. Claim: 2. A gene encoding the fusion protein of claim 1 . Claim: 3. The gene according to claim 2 , wherein the gene consists of the nucleotide sequence of SEQ ID NO: 1 or SEQ ID NO: 3. Claim: 4. A recombinant vector comprising the gene of claim 2 . Claim: 5. A host cell transformed with the recombinant vector of claim 4 , wherein the host cell is Escherichia coli (E. coli). Claim: 6. A method for producing the fusion protein in a host cell, the method comprising: transforming the host cell with the recombinant vector of claim 4 . Claim: 7. The method of claim 6 , wherein the host cell is E. coli. Claim: 8. A composition comprising: a fusion protein having the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4. Claim: 9. The fusion protein of claim 1 , wherein the amino acid sequence is SEQ ID NO: 2. Claim: 10. The fusion protein of claim 1 , wherein the amino acid sequence is SEQ ID NO: 4. Claim: 11. The gene according to claim 2 , wherein the gene has the nucleotide sequence of SEQ ID NO: 1. Claim: 12. The gene according to claim 2 , wherein the gene has the nucleotide sequence of SEQ ID NO: 3. Claim: 13. A recombinant vector comprising the gene of claim 11 . Claim: 14. A recombinant vector comprising the gene of claim 12 . Claim: 15. A host cell transformed with the recombinant vector of claim 13 , wherein the host cell is Escherichia coli (E. coli). Claim: 16. A host cell transformed with the recombinant vector of claim 14 , wherein the host cell is Escherichia coli (E. coli). Claim: 17. A method for producing the fusion protein in a host cell, the method comprising: transforming the host cell with the recombinant vector of claim 13 . Claim: 18. A method for producing in a host cell the fusion protein, the method comprising: transforming the host cell with the recombinant vector of claim 14 . Claim: 19. A method for regenerating skin and improving skin wrinkle of a subject, the method comprising applying the composition of claim 8 to a skin of the subject. Patent References Cited: 2006-083178 March 2006 ; 10-2013-0138563 December 2013 ; 10-1609041 April 2016 ; 10-01652956 August 2016 ; 10-1678392 November 2016 ; WO 2013/184939 December 2013 ; WO 2014/062424 April 2014 Other References: International Search Report for PCT/KR2017/005751 dated Feb. 19, 2018. cited by applicant ; Hanahan, D., “Studies on Transformation of Escherichia coli with Plasmids”, J. Mol. Biol. vol. 166, 557-580, 1983. cited by applicant Assistant Examiner: Sabila, Mercy H Primary Examiner: Sasan, Aradhana Attorney, Agent or Firm: The PL Law Group, PLLC

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