Macro- and micro-structural white matter differences correlate with cognitive performance in healthy aging
Springer, 2016
Online
academicJournal
Zugriff:
Studies have shown that white matter (WM) volumetric reductions and overall degradation occur with aging. Nonetheless little is known about the WM alterations that may underlie different cognitive status in older individuals. The main goal of the present work was to identify and characterize possible macro and microstructural WM alterations that could distinguish between older healthy individuals with contrasting cognitive profiles (i.e., "poor" vs "good" cognitive performers). Structural and diffusion magnetic resonance imaging was performed in order to quantify local WM volumes, white matter signal abnormalities (WMSA) volume (a measure of lesion burden) and diffusion tensor imaging scalar maps known to probe WM microstructure. A battery of neurocognitive/psychological tests was administered to assess the cognitive performance. Poor performers showed a higher slope for the positive association between WMSA volume and age compared to good performers. Even when controlling for WMSA volume, poor performers also evidenced lower fractional anisotropy, as well as positive associations with age with higher slopes of regression parameters in radial and axial diffusivity. Altogether results suggest that cognitive performance is related to differences in WM, with poor cognitive performers displaying signs of faster aging in WM.
SwitchBox-FP7-HEALTH-2010-grant 259772–2 and co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). Paulo Marques, José M. Soares and Nadine C. Santos are supported by Switchbox fellowships. Ricardo Magalhães is supported by a fellowship from the project FCT-ANR/NEU-OSD/0258/2012 funded by FCT/MEC (www.fct.pt) and by FEDER
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Macro- and micro-structural white matter differences correlate with cognitive performance in healthy aging
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Autor/in / Beteiligte Person: | Marques, Paulo César Gonçalves ; Soares, José Miguel Montenegro ; Magalhães, Ricardo José Silva ; Santos, Nadine Correia ; Sousa, Nuno ; Universidade do Minho |
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Veröffentlichung: | Springer, 2016 |
Medientyp: | academicJournal |
DOI: | 10.1007/s11682-015-9378-4 |
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