No advantage of A&bgr;42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studiesSYMBOLSYMBOL
In: Neurology, Jg. 70 (2008-06-10), Heft 24, Part 1 of 2
Online
academicJournal
- 2291 - 2298
IntroductionObservational studies show reduced incidence of Alzheimer dementia (AD) in users of nonsteroidal anti-inflammatory drugs (NSAIDs). One hypothesis holds that the subset of NSAIDs known as selective A beta(42)-lowering agents (SALAs) is responsible for this apparent reduction in AD risk.MethodsWe pooled individual-level data from six prospective studies to obtain a sufficient sample to examine AD risk in users of SALA vs non-SALA NSAIDs.ResultsOf 13,499 initially dementia-free participants (70,863 person-years), 820 developed incident AD. Users of NSAIDs (29.6%) showed reduced risk of AD (adjusted hazard ratio [aHR] 0.77, 95% CI 0.65-0.91). The point estimates were similar for SALAs (aHR 0.87, CI 0.72-1.04) and non-SALAs (aHR 0.75, CI 0.56-1.01). Because 573 NSAID users (14.5%) reported taking both a SALA and non-SALA, we examined their use alone and in combination. Resulting aHRs were 0.82 (CI 0.67-0.99) for SALA only, 0.60 (CI 0.40-0.90) for non-SALA only, and 0.87 (CI 0.57-1.33) for both NSAIDs (Wald test for differences, p = 0.32). The 40.7% of participants who used aspirin also showed reduced risk of AD, even when they used no other NSAIDs (aHR 0.78, CI 0.66-0.92). By contrast, there was no association with use of acetaminophen (aHR 0.93, CI 0.76-1.13).ConclusionsIn this pooled dataset, nonsteroidal anti-inflammatory drug (NSAID) use reduced the risk of Alzheimer dementia (AD). However, there was no apparent advantage in AD risk reduction for the subset of NSAIDs shown to selectively lower A beta(42), suggesting that all conventional NSAIDs including aspirin have a similar protective effect in humans.
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No advantage of A&bgr;42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studiesSYMBOLSYMBOL
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Autor/in / Beteiligte Person: | Szekely, CA ; Green, RC ; Breitner, JCS ; Østbye, T ; Beiser, AS ; Corrada, MM ; Dodge, HH ; Ganguli, M ; Kawas, CH ; Kuller, LH ; Psaty, BM ; Resnick, SM ; Wolf, PA ; Zonderman, AB ; Welsh-Bohmer, KA ; Zandi, PP |
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Zeitschrift: | Neurology, Jg. 70 (2008-06-10), Heft 24, Part 1 of 2 |
Veröffentlichung: | eScholarship, University of California, 2008 |
Medientyp: | academicJournal |
Umfang: | 2291 - 2298 |
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