NDF is a transcription factor that stimulates elongation by RNA polymerase II
In: Genes & Development, Jg. 36 (2022-03-01), Heft 5-6
Online
academicJournal
- 294 - 299
RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. NDF binds directly to Pol II and enhances elongation by a different mechanism than that used by transcription factor TFIIS. Moreover, yeast Pdp3, which is related to NDF, binds to Pol II and stimulates elongation. Thus, NDF is a Pol II binding transcription elongation factor that is localized over gene bodies and is conserved from yeast to humans.
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NDF is a transcription factor that stimulates elongation by RNA polymerase II
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Autor/in / Beteiligte Person: | Fei, Jia ; Xu, Jun ; Li, Ziwei ; Xu, Kevin ; Wang, Dong ; Kassavetis, George A ; Kadonaga, James T |
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Zeitschrift: | Genes & Development, Jg. 36 (2022-03-01), Heft 5-6 |
Veröffentlichung: | eScholarship, University of California, 2022 |
Medientyp: | academicJournal |
Umfang: | 294 - 299 |
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