TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.
In: Leukemia, Jg. 33 (2019-07-01), Heft 7
Online
academicJournal
- 1747 - 1758
Risk stratification is critical in the care of patients with myelodysplastic syndromes (MDS). Approximately 10% have a complex karyotype (CK), defined as more than two cytogenetic abnormalities, which is a highly adverse prognostic marker. However, CK-MDS can carry a wide range of chromosomal abnormalities and somatic mutations. To refine risk stratification of CK-MDS patients, we examined data from 359 CK-MDS patients shared by the International Working Group for MDS. Mutations were underrepresented with the exception of TP53 mutations, identified in 55% of patients. TP53 mutated patients had even fewer co-mutated genes but were enriched for the del(5q) chromosomal abnormality (p 10%), abnormal 3q, abnormal 9, and monosomy 7 as having the greatest survival risk. The poor risk associated with CK-MDS is driven by its association with prognostically adverse TP53 mutations and can be refined by considering clinical and karyotype features.
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TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.
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Autor/in / Beteiligte Person: | Haase, Detlef ; Stevenson, Kristen E ; Neuberg, Donna ; Maciejewski, Jaroslaw P ; Nazha, Aziz ; Sekeres, Mikkael A ; Ebert, Benjamin L ; Garcia-Manero, Guillermo ; Haferlach, Claudia ; Haferlach, Torsten ; Kern, Wolfgang ; Ogawa, Seishi ; Nagata, Yasunobu ; Yoshida, Kenichi ; Graubert, Timothy A ; Walter, Matthew J ; List, Alan F ; Komrokji, Rami S ; Padron, Eric ; Sallman, David ; Papaemmanuil, Elli ; Campbell, Peter J ; Savona, Michael R ; Seegmiller, Adam ; Adès, Lionel ; Fenaux, Pierre ; Shih, Lee-Yung ; Bowen, David ; Groves, Michael J ; Tauro, Sudhir ; Fontenay, Michaela ; Kosmider, Olivier ; Bar-Natan, Michal ; Steensma, David ; Stone, Richard ; Heuser, Michael ; Thol, Felicitas ; Cazzola, Mario ; Malcovati, Luca ; Karsan, Aly ; Ganster, Christina ; Hellström-Lindberg, Eva ; Boultwood, Jacqueline ; Pellagatti, Andrea ; Santini, Valeria ; Quek, Lynn ; Vyas, Paresh ; Tüchler, Heinz ; Greenberg, Peter L ; Bejar, Rafael ; International Working Group for MDS Molecular Prognostic Committee |
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Zeitschrift: | Leukemia, Jg. 33 (2019-07-01), Heft 7 |
Veröffentlichung: | eScholarship, University of California, 2019 |
Medientyp: | academicJournal |
Umfang: | 1747 - 1758 |
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