Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension
In: Hypertension, Jg. 79 (2022-08-01), Heft 8
Online
academicJournal
- 1656 - 1667
BackgroundThe availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure.MethodsWe conducted a multiancestry whole-genome sequencing analysis of blood pressure among 51 456 Trans-Omics for Precision Medicine and Centers for Common Disease Genomics program participants (stage-1). Stage-2 analyses leveraged array data from UK Biobank (N=383 145), Million Veteran Program (N=318 891), and Reasons for Geographic and Racial Differences in Stroke (N=10 643) participants, along with whole-exome sequencing data from UK Biobank (N=199 631) participants.ResultsTwo blood pressure signals achieved genome-wide significance in meta-analyses of stage-1 and stage-2 single variant findings (P
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Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension
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| Autor/in / Beteiligte Person: | Kelly, Tanika N ; Sun, Xiao ; He, Karen Y ; Brown, Michael R ; Taliun, Sarah A Gagliano ; Hellwege, Jacklyn N ; Irvin, Marguerite R ; Mi, Xuenan ; Brody, Jennifer A ; Franceschini, Nora ; Guo, Xiuqing ; Hwang, Shih-Jen ; de Vries, Paul S ; Gao, Yan ; Moscati, Arden ; Nadkarni, Girish N ; Yanek, Lisa R ; Elfassy, Tali ; Smith, Jennifer A ; Chung, Ren-Hua ; Beitelshees, Amber L ; Patki, Amit ; Aslibekyan, Stella ; Blobner, Brandon M ; Peralta, Juan M ; Assimes, Themistocles L ; Palmas, Walter R ; Liu, Chunyu ; Bress, Adam P ; Huang, Zhijie ; Becker, Lewis C ; Hwa, Chii-Min ; O’Connell, Jeffrey R ; Carlson, Jenna C ; Warren, Helen R ; Das, Sayantan ; Giri, Ayush ; Martin, Lisa W ; Johnson, W Craig ; Fox, Ervin R ; Bottinger, Erwin P ; Razavi, Alexander C ; Vaidya, Dhananjay ; Chuang, Lee-Ming ; Chang, Yen-Pei C ; Naseri, Take ; Jain, Deepti ; Kang, Hyun Min ; Hung, Adriana M ; Srinivasasainagendra, Vinodh ; Snively, Beverly M ; Gu, Dongfeng ; Montasser, May E ; Reupena, Muagututi A Sefuiva ; Heavner, Benjamin D ; LeFaive, Jonathon ; Hixson, James E ; Rice, Kenneth M ; Wang, Fei Fei ; Nielsen, Jonas B ; Huang, Jianfeng ; Khan, Alyna T ; Zhou, Wei ; Nierenberg, Jovia L ; Laurie, Cathy C ; Armstrong, Nicole D ; Shi, Mengyao ; Pan, Yang ; Stilp, Adrienne M ; Emery, Leslie ; Wong, Quenna ; Hawley, Nicola L ; Minster, Ryan L ; Curran, Joanne E ; Munroe, Patricia B ; Weeks, Daniel E ; North, Kari E ; Tracy, Russell P ; Kenny, Eimear E ; Shimbo, Daichi ; Chakravarti, Aravinda ; Rich, Stephen S ; Reiner, Alex P ; Blangero, John ; Redline, Susan ; Mitchell, Braxton D ; Rao, Dabeeru C ; Chen, Yii-Der Ida ; Kardia, Sharon LR ; Kaplan, Robert C ; Mathias, Rasika A ; He, Jiang ; Psaty, Bruce M ; Fornage, Myriam ; Loos, Ruth JF ; Correa, Adolfo ; Boerwinkle, Eric ; Rotter, Jerome I ; Kooperberg, Charles ; Edwards, Todd L |
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| Zeitschrift: | Hypertension, Jg. 79 (2022-08-01), Heft 8 |
| Veröffentlichung: | eScholarship, University of California, 2022 |
| Medientyp: | academicJournal |
| Umfang: | 1656 - 1667 |
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