Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis
In: Science Advances, Jg. 9 (2023-06-09), Heft 23
Online
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- eabq7595
Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral and cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients presents a clinical challenge, and novel noninvasive imaging biomarkers are urgently needed. Here, we demonstrate that visualization of the translocator protein (TSPO) with [18F]DPA-714-PET-MRI reveals pronounced microglia activation and reactive gliosis in the hippocampus and amygdala of patients suspected with CD8 T cell ALE, which correlates with FLAIR-MRI and EEG alterations. Back-translation into a preclinical mouse model of neuronal antigen-specific CD8 T cell-mediated ALE allowed us to corroborate our preliminary clinical findings. These translational data underline the potential of [18F]DPA-714-PET-MRI as a clinical molecular imaging method for the direct assessment of innate immunity in CD8 T cell-mediated ALE.
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Translational imaging of TSPO reveals pronounced innate inflammation in human and murine CD8 T cell–mediated limbic encephalitis
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Autor/in / Beteiligte Person: | Gallus, Marco ; Roll, Wolfgang ; Dik, Andre ; Barca, Cristina ; Zinnhardt, Bastian ; Hicking, Gordon ; Mueller, Christoph ; Naik, Venu Narayanan ; Anstötz, Max ; Krämer, Julia ; Rolfes, Leoni ; Wachsmuth, Lydia ; Pitsch, Julika ; van Loo, Karen MJ ; Räuber, Saskia ; Okada, Hideho ; Wimberley, Catriona ; Strippel, Christine ; Golombeck, Kristin S ; Johnen, Andreas ; Kovac, Stjepana ; Groß, Catharina C ; Backhaus, Philipp ; Seifert, Robert ; Lewerenz, Jan ; Surges, Rainer ; Elger, Christian E ; Wiendl, Heinz ; Ruck, Tobias ; Becker, Albert J ; Faber, Cornelius ; Jacobs, Andreas H ; Bauer, Jan ; Meuth, Sven G ; Schäfers, Michael ; Melzer, Nico |
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Zeitschrift: | Science Advances, Jg. 9 (2023-06-09), Heft 23 |
Veröffentlichung: | eScholarship, University of California, 2023 |
Medientyp: | academicJournal |
Umfang: | eabq7595 |
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