Rare genetic variants explain missing heritability in smoking.
In: Nature human behaviour, Jg. 6 (2022-11-01), Heft 11
Online
academicJournal
- 1577 - 1586
Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability ([Formula: see text]) was estimated from 0.13 to 0.28 (s.e., 0.10-0.13) in European ancestries, with 35-74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5-4 times higher than past estimates based on common variants alone and accounted for 60% to 100% of our pedigree-based estimates of narrow-sense heritability ([Formula: see text], 0.18-0.34). In the African ancestry samples, [Formula: see text] was estimated from 0.03 to 0.33 (s.e., 0.09-0.14) across the four smoking traits. These results suggest that rare variants are important contributors to the heritability of smoking.
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Rare genetic variants explain missing heritability in smoking.
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Autor/in / Beteiligte Person: | Jang, Seon-Kyeong ; Evans, Luke ; Fialkowski, Allison ; Arnett, Donna K ; Ashley-Koch, Allison E ; Barnes, Kathleen C ; Becker, Diane M ; Bis, Joshua C ; Blangero, John ; Bleecker, Eugene R ; Boorgula, Meher Preethi ; Bowden, Donald W ; Brody, Jennifer A ; Cade, Brian E ; Jenkins, Brenda W Campbell ; Carson, April P ; Chavan, Sameer ; Cupples, L Adrienne ; Custer, Brian ; Damrauer, Scott M ; David, Sean P ; de Andrade, Mariza ; Dinardo, Carla L ; Fingerlin, Tasha E ; Fornage, Myriam ; Freedman, Barry I ; Garrett, Melanie E ; Gharib, Sina A ; Glahn, David C ; Haessler, Jeffrey ; Heckbert, Susan R ; Hokanson, John E ; Hou, Lifang ; Hwang, Shih-Jen ; Hyman, Matthew C ; Judy, Renae ; Justice, Anne E ; Kaplan, Robert C ; Kardia, Sharon LR ; Kelly, Shannon ; Kim, Wonji ; Kooperberg, Charles ; Levy, Daniel ; Lloyd-Jones, Donald M ; Loos, Ruth JF ; Manichaikul, Ani W ; Gladwin, Mark T ; Martin, Lisa Warsinger ; Nouraie, Mehdi ; Melander, Olle ; Meyers, Deborah A ; Montgomery, Courtney G ; North, Kari E ; Oelsner, Elizabeth C ; Palmer, Nicholette D ; Payton, Marinelle ; Peljto, Anna L ; Peyser, Patricia A ; Preuss, Michael ; Psaty, Bruce M ; Qiao, Dandi ; Rader, Daniel J ; Rafaels, Nicholas ; Redline, Susan ; Reed, Robert M ; Reiner, Alexander P ; Rich, Stephen S ; Rotter, Jerome I ; Schwartz, David A ; Shadyab, Aladdin H ; Silverman, Edwin K ; Smith, Nicholas L ; Smith, J Gustav ; Smith, Albert V ; Smith, Jennifer A ; Tang, Weihong ; Taylor, Kent D ; Telen, Marilyn J ; Vasan, Ramachandran S ; Gordeuk, Victor R ; Wang, Zhe ; Wiggins, Kerri L ; Yanek, Lisa R ; Yang, Ivana V ; Young, Kendra A ; Young, Kristin L ; Zhang, Yingze ; Liu, Dajiang J ; Keller, Matthew C ; Vrieze, Scott |
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Zeitschrift: | Nature human behaviour, Jg. 6 (2022-11-01), Heft 11 |
Veröffentlichung: | eScholarship, University of California, 2022 |
Medientyp: | academicJournal |
Umfang: | 1577 - 1586 |
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