Thresholds for PSA doubling time in men with non‐metastatic castration‐resistant prostate cancer
In: BJU International, Jg. 120 (2017-11-01), Heft 5B
Online
academicJournal
- e80 - e86
ObjectivesTo examine whether prostate-specific antigen doubling time (PSADT) correlates with metastases, all-cause mortality (ACM), and prostate cancer-specific mortality (PCSM) and to identify PSADT thresholds that can be used clinically for risk stratification in men with M0 castration-resistant prostate cancer (CRPC).Materials and methodsWe collected data on 441 men with M0 CRPC in 2000-2015 at five Veterans Affairs hospitals. Cox models were used to test the association between log-transformed PSADT and the development of metastasis, ACM and PCSM. To identify thresholds, we categorized PSADT into 3-month groups and then combined groups with similar hazard ratios (HRs).ResultsThe median (interquartile range) follow-up was 28.3 (14.7-49.1) months. As a continuous variable, PSADT was associated with metastases, ACM and PCSM (HR 1.40-1.68, all P < 0.001). We identified the following PSADT thresholds:
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Thresholds for PSA doubling time in men with non‐metastatic castration‐resistant prostate cancer
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| Autor/in / Beteiligte Person: | Howard, Lauren E ; Moreira, Daniel M ; De Hoedt, Amanda ; Aronson, William J ; Kane, Christopher J ; Amling, Christopher L ; Cooperberg, Matthew R ; Terris, Martha K ; Freedland, Stephen J |
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| Zeitschrift: | BJU International, Jg. 120 (2017-11-01), Heft 5B |
| Veröffentlichung: | eScholarship, University of California, 2017 |
| Medientyp: | academicJournal |
| Umfang: | e80 - e86 |
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