Allogeneic stem-cell transplantation in patients with cutaneous lymphoma: updated results from a single institution.
In: Annals of Oncology, Jg. 26 (2015-12-01), Heft 12
Online
academicJournal
BACKGROUND: Cutaneous T-cell lymphomas (CTCLs) and its common variants mycosis fungoides (MF) and leukemic Sézary syndrome (SS) are rare extranodal non-Hodgkins lymphomas. Patients who present with advanced disease and large-cell transformation (LCT) are incurable with standard treatments. In this article, we report the largest single-center experience with allogeneic stem-cell transplantation (SCT) for advanced CTCL. PATIENTS AND METHODS: This is a prospective case series of 47 CTCL patients who underwent allogeneic SCT after failure of standard therapy between July 2001 and September 2013. The Kaplan-Meier method was used to estimate overall survival (OS) and progression-free survival (PFS) curves. The method of Fine and Gray was used to fit regression models to the same covariates for these cumulative incidence data. RESULTS: The Kaplan-Meier estimates of OS and PFS at 4 years were 51% and 26%, respectively. There was no statistical difference in the OS in patients who had MF alone, SS, MF with LCT, or SS with LCT. PFS at 4 years was superior in patients who had SS versus those who did not (52.4% versus 9.9%; P = 0.02). The cumulative incidences of grade 2-4 acute graft-versus-host disease (GVHD) and chronic GVHD were 40% and 28%, respectively. The cumulative nonrelapse mortality rate was 16.7% at 2 years. CONCLUSION: Allogeneic SCT may result in long-term remissions in a subset of patients with advanced CTCL. Although post-SCT relapse rates are high, many patients respond to immunomodulation and achieve durable remissions. CLINICALTRIALSGOV: NCT00506129.
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Allogeneic stem-cell transplantation in patients with cutaneous lymphoma: updated results from a single institution.
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Autor/in / Beteiligte Person: | Hosing, C ; Bassett, R ; Dabaja, B ; Talpur, R ; Alousi, A ; Ciurea, S ; Popat, U ; Qazilbash, M ; Shpall, E ; Oki, Y ; Nieto, Y ; Pinnix, C ; Fanale, M ; Maadani, F ; Donato, M ; Champlin, R ; Duvic, M |
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Zeitschrift: | Annals of Oncology, Jg. 26 (2015-12-01), Heft 12 |
Veröffentlichung: | eScholarship, University of California, 2015 |
Medientyp: | academicJournal |
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