Long-term intra- and inter-individual biological variation of serum lipid of HIV-infected and uninfected men participating in the Los Angeles Multi-Center AIDS Cohort Study (MACS)

Aziz, Najib ; Gjertson, David W ; et al.

In: Lipids in Health and Disease, Jg. 21 (2022-12-01), Heft 1

Online academicJournal - 63

Zugriff:

BackgroundTo assess the long-term biological coefficient of variation within individuals (CVI) and between individuals (CVG), effect of aging and cholesterol lowering drugs on blood levels of lipids in HIV-1-infected and -uninfected men.MethodsBloods were analyzed every six months over 17 years for total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in 140 HIV-uninfected (38-66 years old) and 90 HIV-treated infected (48-64 years old) white Caucasian men to examine CVI, CVG, and the effect of cholesterol lowering drugs (CLDs) on lipid levels, and estimated changes per year of biomarkers.ResultsWith exception of HDL-C, the long term CVI compared with CVG were higher for serum levels of TC, TGs, and LDL-C in both HIV-1 infected and uninfected men not taking CLDs. Excluding results of TGs in HIV positive men, the CVI compared with CVG were lower for serum levels of TC, HDL-C, and LDL-C in both groups not taking CLDs. There were significant (p

Titel:	Long-term intra- and inter-individual biological variation of serum lipid of HIV-infected and uninfected men participating in the Los Angeles Multi-Center AIDS Cohort Study (MACS)
Autor/in / Beteiligte Person:	Aziz, Najib ; Gjertson, David W ; Mimiaga, Matthew J ; Azarkman, Chantel D ; Soto, Rey ; Alexopoulos, Nicole ; Detels, Roger
Link:	View record in eScholarship (Volltext)
Zeitschrift:	Lipids in Health and Disease, Jg. 21 (2022-12-01), Heft 1
Veröffentlichung:	eScholarship, University of California, 2022
Medientyp:	academicJournal
Umfang:	63
Schlagwort:	Biomedical and Clinical Sciences Clinical Sciences Cardiovascular Atherosclerosis HIV/AIDS Infectious Diseases Infection Acquired Immunodeficiency Syndrome Adult Aged Anticholesteremic Agents Antiretroviral Therapy Highly Active Biological Variation Population Biomarkers Cholesterol HDL LDL Cohort Studies HIV Infections HIV-1 Humans Los Angeles Male Middle Aged Triglycerides Biological variation CVI CVG HDL-C Other Information and Computing Sciences Medical Biochemistry and Metabolomics Nutrition and Dietetics Nutrition & Dietetics Medical biochemistry and metabolomics Nutrition and dietetics
Sonstiges:	Nachgewiesen in: eScholarship Document Type: article File Description: application/pdf Rights: public

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