Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
In: Cell Genomics, Jg. 4 (2024), Heft 1
Online
academicJournal
- 100468
Chronic kidney disease is a leading cause of death and disability globally and impacts individuals of African ancestry (AFR) or with ancestry in the Americas (AMS) who are under-represented in genome-wide association studies (GWASs) of kidney function. To address this bias, we conducted a large meta-analysis of GWASs of estimated glomerular filtration rate (eGFR) in 145,732 AFR and AMS individuals. We identified 41 loci at genome-wide significance (p
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Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
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| Autor/in / Beteiligte Person: | Hughes, Odessica ; Bentley, Amy R ; Breeze, Charles E ; Aguet, Francois ; Xu, Xiaoguang ; Nadkarni, Girish ; Sun, Quan ; Lin, Bridget M ; Gilliland, Thomas ; Meyer, Mariah C ; Du, Jiawen ; Raffield, Laura M ; Kramer, Holly ; Morton, Robert W ; Gouveia, Mateus H ; Atkinson, Elizabeth G ; Valladares-Salgado, Adan ; Wacher-Rodarte, Niels ; Dueker, Nicole D ; Guo, Xiuqing ; Hai, Yang ; Adeyemo, Adebowale ; Best, Lyle G ; Cai, Jianwen ; Chen, Guanjie ; Chong, Michael ; Doumatey, Ayo ; Eales, James ; Goodarzi, Mark O ; Ipp, Eli ; Irvin, Marguerite Ryan ; Jiang, Minzhi ; Jones, Alana C ; Kooperberg, Charles ; Krieger, Jose E ; Lange, Ethan M ; Lanktree, Matthew B ; Lash, James P ; Lotufo, Paulo A ; Loos, Ruth JF ; My, Vy Thi Ha ; Peralta-Romero, Jesús ; Qi, Lihong ; Raffel, Leslie J ; Rich, Stephen S ; Rodriquez, Erik J ; Tarazona-Santos, Eduardo ; Taylor, Kent D ; Umans, Jason G ; Wen, Jia ; Young, Bessie A ; Yu, Zhi ; Zhang, Ying ; Chen, Yii-Der Ida ; Rundek, Tanja ; Rotter, Jerome I ; Cruz, Miguel ; Fornage, Myriam ; Lima-Costa, Maria Fernanda ; Pereira, Alexandre C ; Paré, Guillaume ; Natarajan, Pradeep ; Cole, Shelley A ; Carson, April P ; Lange, Leslie A ; Li, Yun ; Perez-Stable, Eliseo J ; Do, Ron ; Charchar, Fadi J ; Tomaszewski, Maciej ; Mychaleckyj, Josyf C ; Rotimi, Charles ; Morris, Andrew P ; Franceschini, Nora |
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| Zeitschrift: | Cell Genomics, Jg. 4 (2024), Heft 1 |
| Veröffentlichung: | eScholarship, University of California, 2024 |
| Medientyp: | academicJournal |
| Umfang: | 100468 |
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