Carbon nanotube substrates enhance SARS-CoV-2 spike protein ion yields in matrix-assisted laser desorption–ionization mass spectrometry
In: Applied Physics Letters, Jg. 122 (2023-01-30), Heft 5
Online
academicJournal
- 050601
Nanostructured surfaces enhance ion yields in matrix-assisted laser desorption-ionization mass spectrometry (MALDI-MS). The spike protein complex, S1, is one fingerprint signature of Sars-CoV-2 with a mass of 75 kDa. Here, we show that MALDI-MS yields of Sars-CoV-2 spike protein ions in the 100 kDa range are enhanced 50-fold when the matrix-analyte solution is placed on substrates that are coated with a dense forest of multi-walled carbon nanotubes, compared to yields from uncoated substrates. Nanostructured substrates can support the development of mass spectrometry techniques for sensitive pathogen detection and environmental monitoring.
Titel: |
Carbon nanotube substrates enhance SARS-CoV-2 spike protein ion yields in matrix-assisted laser desorption–ionization mass spectrometry
|
---|---|
Autor/in / Beteiligte Person: | Schenkel, T ; Snijders, AM ; Nakamura, K ; Seidl, PA ; Mak, B ; Obst-Huebl, L ; Knobel, H ; Pong, I ; Persaud, A ; van Tilborg, J ; Ostermayr, T ; Steinke, S ; Blakely, EA ; Ji, Q ; Javey, A ; Kapadia, R ; Geddes, CGR ; Esarey, E |
Link: | |
Zeitschrift: | Applied Physics Letters, Jg. 122 (2023-01-30), Heft 5 |
Veröffentlichung: | eScholarship, University of California, 2023 |
Medientyp: | academicJournal |
Umfang: | 050601 |
Schlagwort: |
|
Sonstiges: |
|