CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection
In: Clinical Infectious Diseases, Jg. 62 (2016-02-01), Heft 3
Online
academicJournal
- 392 - 396
BackgroundPersistent CD8 T-cell expansion, low CD4/CD8 T-cell ratios, and heightened inflammation persist in antiretroviral therapy (ART)-treated human immunodeficiency virus (HIV) infection and are associated with increased risk of morbid outcomes. We explored the role of cytomegalovirus (CMV) infection in CD8 lymphocytosis and inflammation in ART-treated HIV infection.MethodsAbsolute CD4 and CD8 T-cell counts were abstracted from clinical records and compared among 32 HIV-infected CMV-seronegative subjects, 126 age, CD4 and gender-matched HIV-infected CMV-seropositive subjects, and among 21 HIV-uninfected controls (9 CMV-negative, 12 CMV-positive). Plasma inflammatory indices were measured in a subset by ELISA.ResultsMedian CD8 counts/µL were higher in HIV-positive/CMV-positive patients (795) than in HIV-positive/CMV-negative subjects (522, P = .006) or in healthy controls (451, P = .0007), whereas CD8 T-cell counts were similar to controls' levels in HIV-positive/CMV-negative subjects. Higher plasma levels of IP-10 (P = .0011), TNF-RII (P = .0002), and D-dimer (P = .0444) were also found in coinfected patients than in HIV-positive/CMV-negative subjects.ConclusionsCMV infection is associated with higher CD8 T-cell counts, resultant lower CD4/CD8 ratios, and increased systemic inflammation in ART-treated HIV infection. CMV infection may contribute to risk for morbid outcomes in treated HIV infection.
Titel: |
CD8 T-Cell Expansion and Inflammation Linked to CMV Coinfection in ART-treated HIV Infection
|
---|---|
Autor/in / Beteiligte Person: | Freeman, Michael L ; Mudd, Joseph C ; Shive, Carey L ; Younes, Souheil-Antoine ; Panigrahi, Soumya ; Sieg, Scott F ; Lee, Sulggi A ; Hunt, Peter W ; Calabrese, Leonard H ; Gianella, Sara ; Rodriguez, Benigno ; Lederman, Michael M |
Link: | |
Zeitschrift: | Clinical Infectious Diseases, Jg. 62 (2016-02-01), Heft 3 |
Veröffentlichung: | eScholarship, University of California, 2016 |
Medientyp: | academicJournal |
Umfang: | 392 - 396 |
Schlagwort: |
|
Sonstiges: |
|