Ribp, a Novel Rlk/Txk- and Itk-Binding Adaptor Protein That Regulates T Cell Activation
In: Journal of Experimental Medicine, Jg. 190 (1999-12-06), Heft 11
Online
academicJournal
- 1657 - 1668
A novel T cell-specific adaptor protein, RIBP, was identified based on its ability to bind Rlk/Txk in a yeast two-hybrid screen of a mouse T cell lymphoma library. RIBP was also found to interact with a related member of the Tec family of tyrosine kinases, Itk. Expression of RIBP is restricted to T and natural killer cells and is upregulated substantially after T cell activation. RIBP-disrupted knockout mice displayed apparently normal T cell development. However, proliferation of RIBP-deficient T cells in response to T cell receptor (TCR)-mediated activation was significantly impaired. Furthermore, these activated T cells were defective in the production of interleukin (IL)-2 and interferon gamma, but not IL-4. These data suggest that RIBP plays an important role in TCR-mediated signal transduction pathways and that its binding to Itk and Rlk/Txk may regulate T cell differentiation.
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Ribp, a Novel Rlk/Txk- and Itk-Binding Adaptor Protein That Regulates T Cell Activation
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Autor/in / Beteiligte Person: | Rajagopal, Keshava ; Sommers, Connie L ; Decker, Donna C ; Mitchell, Elizabeth O ; Korthauer, Ulf ; Sperling, Anne I ; Kozak, Christine A ; Love, Paul E ; Bluestone, Jeffrey A |
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Zeitschrift: | Journal of Experimental Medicine, Jg. 190 (1999-12-06), Heft 11 |
Veröffentlichung: | eScholarship, University of California, 1999 |
Medientyp: | academicJournal |
Umfang: | 1657 - 1668 |
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