Maintenance of Investigators Static Global Assessment Response with Once-Daily Crisaborole in Participants with Mild to Moderate Atopic Dermatitis.
In: Dermatology and Therapy, Jg. 14 (2024-04-01), Heft 4
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INTRODUCTION: Treatments for atopic dermatitis (AD) often fail to achieve lasting disease control. In the CrisADe CONTROL phase III study (ClinicalTrials.gov: NCT04040192), participants aged ≥ 3 months with mild to moderate AD treated with once-daily (QD) crisaborole, following initial treatment success with crisaborole twice daily (BID), had longer periods of flare-free maintenance, a higher number of flare-free days, and a lower number of flares compared with those who received vehicle. The study was an exploratory analysis of data on the maintenance of response per Investigators Static Global Assessment (ISGA; ISGA score of 0 [clear] or 1 [almost clear]) during the CrisADe CONTROL study through week 52. METHODS: Exploratory endpoints were the time to ISGA response during the open-label run-in period, and the maintenance of ISGA response and the severity and duration of flares during the double-blind maintenance period. Outcomes were stratified by age (participants aged 3 months to
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Maintenance of Investigators Static Global Assessment Response with Once-Daily Crisaborole in Participants with Mild to Moderate Atopic Dermatitis.
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Autor/in / Beteiligte Person: | Stein Gold, Linda ; Lynde, Charles ; Guenther, Lyn ; Greenberger, Shoshana ; Chu, Chia-Yu ; Ghodsi, Zara ; Vlahos, Bonnie ; Sanders, Paul ; Cha, Amy ; Canosa, Juliana ; Eichenfield, Lawrence |
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Zeitschrift: | Dermatology and Therapy, Jg. 14 (2024-04-01), Heft 4 |
Veröffentlichung: | eScholarship, University of California, 2024 |
Medientyp: | academicJournal |
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