Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil
In: Memórias do Instituto Oswaldo Cruz, Jg. 102 (2007-02-01), Heft 1
Online
academicJournal
Zugriff:
Resistance in Mycobacterium tuberculosis to isoniazid (INH) is caused by mutations in the catalase-peroxidase gene (katG) , and within the inhA promoter and/or in structural gene. A small percentage (~ 10%) of INH-resistant strains do not present mutations in both of these loci. Other genes have been associated with INH resistance including the gene encoding for NADH dehydrogenase (ndh) . Here we report the detection of two ndh locus mutations (CGT to TGT change in codon 13 and GTG to GCG change in codon 18) by analyzing 23 INH-resistant and in none of 13 susceptible isolates from Brazilian tuberculosis patients. We also detected two isolates without a mutation in ndh, or any of the other INH resistance-associated loci examined, suggesting the existence of additional, as yet to be described, INH resistance mechanisms.
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Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil
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Autor/in / Beteiligte Person: | Cardoso, Rosilene Fressatti ; Cardoso, Marco Antonio ; Leite, Clarice Queico Fujimura ; Sato, Daisy Nakamura ; Mamizuka, Elsa Masae ; Hirata, Rosário Dominguez Crespo ; Mello, Fernando Fiúza de ; Hirata, Mario Hiroyuki |
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Zeitschrift: | Memórias do Instituto Oswaldo Cruz, Jg. 102 (2007-02-01), Heft 1 |
Veröffentlichung: | Instituto Oswaldo Cruz, Ministério da Saúde, 2007 |
Medientyp: | academicJournal |
ISSN: | 0074-0276 (print) |
DOI: | 10.1590/S0074-02762007000100009 |
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