In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells
In: Brazilian Journal of Medical and Biological Research, Jg. 34 (2001-10-01), Heft 10
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Zugriff:
Acute myelogenous leukemia (AML) blast cells show high-affinity degradation of low-density lipoprotein (LDL), suggesting an increased expression of cellular LDL receptors. LDE is a lipid microemulsion easily synthesized in vitro which is known to mimic the metabolic pathway of LDL. We used LDE as a carrier for daunorubicin and assayed the cytotoxicity of the complex using AML blast cells since RT-PCR analysis showed that AML cells express LDL receptor mRNA. The LDE:daunorubicin complex killed 46.7% of blast cells and 20.2% of normal bone marrow cells (P<0.001; Student t-test). Moreover, this complex destroyed AML blast cells as efficiently as free daunorubicin. Thus, LDE might be a suitable carrier of chemotherapeutic agents targeting these drugs to neoplastic cells and protecting normal tissues.
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In vitro cytotoxicity of the LDE: daunorubicin complex in acute myelogenous leukemia blast cells
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Autor/in / Beteiligte Person: | Dorlhiac-Llacer, P.E. ; Marquezini, M.V. ; Toffoletto, O. ; Carneiro, R.C.G. ; Maranhão, R.C. ; Chamone, D.A.F. |
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Zeitschrift: | Brazilian Journal of Medical and Biological Research, Jg. 34 (2001-10-01), Heft 10 |
Veröffentlichung: | Associação Brasileira de Divulgação Científica, 2001 |
Medientyp: | academicJournal |
ISSN: | 0100-879X (print) |
DOI: | 10.1590/S0100-879X2001001000004 |
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