Salvianolic acid A alleviates the renal damage in rats with chronic renal failure
In: Acta Cirúrgica Brasileira, Jg. 34 (2019), Heft 2
Online
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Zugriff:
Purpose: To investigate the protective effects of salvianolic acid A (SAA) on renal damage in rats with chronic renal failure (CRF). Methods: The five-sixth nephrectomy model of CRF was successfully established in group CRF (10 rats) and group CRF+SAA (10 rats). Ten rats were selected as sham-operated group (group S), in which only the capsules of both kidneys were removed. The rats in group CRF+SAA were intragastrically administrated with 10 mg/kg SAA for 8 weeks. The blood urine nitrogen (BUN), urine creatinine (Ucr), creatinine clearance rate (Ccr), and serum uperoxide dismutase (SOD) and malondialdehyde (MDA) were tested. The expressions of transforming growth factor-β1 (TGF-β1), bone morphogenetic protein 7 (BMP-7) and Smad6 protein in renal tissue were determined. Results: After treatment, compared with group CRF, in group CRF+SAA the BUN, Scr, serum MDA and kidney/body weight ratio were decreased, the Ccr and serum SOD were increased, the TGF-β1 protein expression level in renal tissue was decreased, and the BMP-7 and Smad6 protein levels were increased (all P < 0.05). Conclusion: SAA can alleviate the renal damage in CRF rats through anti-oxidant stress, down-regulation of TGF-β1 signaling pathway and up-regulation of BMP-7/Smad6 signaling pathway.
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Salvianolic acid A alleviates the renal damage in rats with chronic renal failure
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Autor/in / Beteiligte Person: | Zhang, Guangming ; Cui, Guanghua ; Tong, Shuangxi ; Cao, Qingxian |
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Zeitschrift: | Acta Cirúrgica Brasileira, Jg. 34 (2019), Heft 2 |
Veröffentlichung: | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2019 |
Medientyp: | academicJournal |
ISSN: | 0102-8650 (print) |
DOI: | 10.1590/s0102-8650201900204 |
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