Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells
In: Arthritis Research & Therapy, Jg. 6 (2004), Heft 6
Online
unknown
Zugriff:
Antibodies against type II collagen (anti-CII) are arthritogenic and have a crucial role in the initiation of collagen-induced arthritis. Here, we have determined the dependence of T and B cells in collagen-antibody-induced arthritis (CAIA) during different phases of arthritis. Mice deficient for B and/or T cells were susceptible to the CAIA, showing that the antibodies induce arthritis even in the absence of an adaptive immune system. To determine whether CII-reactive T cells could have a role in enhancing arthritis development at the effector level of arthritis pathogenesis, we established a T cell line reactive with CII. This T cell line was oligoclonal and responded to different post-translational forms of the major CII epitope at position 260-270 bound to the Aq class II molecule. Importantly, it cross-reacted with the mouse peptide although it is bound with lower affinity to the Aq molecule than the corresponding rat peptide. The T cell line could not induce clinical arthritis per se in Aq-expressing mice even if these mice expressed the major heterologous CII epitope in cartilage, as in the transgenic MMC (mutated mouse collagen) mouse. However, a combined treatment with anti-CII monoclonal antibodies and CII-reactive T cells enhanced the progression of severe arthritis.
Titel: |
Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells
|
---|---|
Autor/in / Beteiligte Person: | Nandakumar, Kutty Selva ; Bäcklund, J. ; Vestberg, M. ; Holmdahl, R. |
Link: | |
Zeitschrift: | Arthritis Research & Therapy, Jg. 6 (2004), Heft 6 |
Veröffentlichung: | 2004 |
Medientyp: | unknown |
ISSN: | 1478-6354 (print) ; 1478-6362 (print) |
DOI: | 10.1186/ar1217 |
Schlagwort: |
|
Sonstiges: |
|