Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis
In: Acta Cardiologica, Jg. 76 (2021), Heft 5, S. 544-544
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Zugriff:
Background Histopathological changes in calcific aortic stenosis (CAS) resemble changes in coronary atherosclerosis. Concerning recent evidence on dietary and gut microbiota-related metabolites representing players in atherosclerosis, we aimed to investigate the link between dietary and gut microbiota-derived metabolites and CAS. Methods We consecutively recruited eligible subjects with moderate-severe CAS (n = 60), aortic sclerosis (ASc) (n = 49) and age and gender-matched control subjects (n = 48) in May 2016-December 2016. Plasma dietary and gut microbiota-related metabolite levels, namely choline, betaine, and trimethylamine N-oxide (TMAO), were measured using ultra-performance liquid chromatography-tandem mass spectroscopy method. Histopathological examinations were performed in patients that underwent aortic valve surgery. Results Prevalence of traditional cardiovascular risk factors or co-morbidities did not differ among groups (all p > 0.05). CAS patients had higher plasma choline levels compared to both control (p < 0.001) and ASc (p = 0.006). Plasma betaine and TMAO levels were similar (both p > 0.05). Compared to the lowest quartile choline levels (<11.15 mu M), patients with the highest quartile choline levels (>= 14.98 mu M) had higher aortic valvular (p < 0.001) and mitral annular (p = 0.013) calcification scores. Plasma choline levels were independently associated with aortic peak flow velocity (B +/- SE:0.165 +/- 0.060, p = 0.009). Choline levels were elevated in subjects who had aortic valves with denser lymphocyte infiltration (p < 0.001), neovascularization (p = 0.011), osseous metaplasia (p = 0.004), more severe tissue remodelling (p = 0.002) and calcification (p = 0.002). Conclusion We found a significant association between choline levels and CAS presence and severity depicted on imaging modalities and histopathological examinations. Our study may open new horizons for prevention of CAS.
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Association of dietary and gut microbiota-related metabolites with calcific aortic stenosis
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Autor/in / Beteiligte Person: | Duygu, K. ; Tokgozoglu, L. ; Gurses, K. M. ; Ståhlman, Marcus ; Borén, Jan ; Soyal, M. F. T. ; Canpinar, H. ; Guc, D. ; Ayhan, A. S. ; Hazirolan, T. ; Ozer, N. |
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Zeitschrift: | Acta Cardiologica, Jg. 76 (2021), Heft 5, S. 544-544 |
Veröffentlichung: | 2021 |
Medientyp: | unknown |
ISSN: | 0001-5385 (print) |
DOI: | 10.1080/00015385.2020.1853968 |
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