Postsynaptic Effects of 'Aplysia' Cysteine-Rich Neurotrophic Factor in the Induction of Activity-Dependent Long-Term Facilitation in 'Aplysia Californica'
In: Learning & Memory, Jg. 27 (2020-04-01), Heft 4, S. 124-129
Online
academicJournal
Zugriff:
The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory formation. We investigated the spatiotemporal dynamics of "Aplysia" cysteine-rich neurotrophic factor (ApCRNF) signaling during the induction of activity-dependent long-term facilitation (AD-LTF) at sensory-to-motor neuron synapses that mediate defensive reflexes in "Aplysia." We found that ApCRNF signaling is required for the induction of AD-LTF, and for training-induced early protein kinase activation and late forms of gene expression, exclusively in postsynaptic neurons. These results support the view that ApCRNF is critically involved in AD-LTF at least in part through postsynaptic mechanisms.
Titel: |
Postsynaptic Effects of 'Aplysia' Cysteine-Rich Neurotrophic Factor in the Induction of Activity-Dependent Long-Term Facilitation in 'Aplysia Californica'
|
---|---|
Autor/in / Beteiligte Person: | Alexandrescu, Anamaria ; Carew, Thomas J. |
Link: | |
Zeitschrift: | Learning & Memory, Jg. 27 (2020-04-01), Heft 4, S. 124-129 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1072-0502 (print) |
DOI: | 10.1101/lm.051011.119 |
Schlagwort: |
|
Sonstiges: |
|