Family-Based Genome-Wide Association Scan of Attention-Deficit/Hyperactivity Disorder
In: Journal of the American Academy of Child & Adolescent Psychiatry, Jg. 49 (2010-09-01), Heft 9, S. 898-905
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Zugriff:
Objective: Genes likely play a substantial role in the etiology of attention-deficit/hyperactivity disorder (ADHD). However, the genetic architecture of the disorder is unknown, and prior genome-wide association studies (GWAS) have not identified a genome-wide significant association. We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD. Method: Families were ascertained at Massachusetts General Hospital (MGH; N = 309 trios), Washington University at St. Louis (WASH-U; N = 272 trios), and University of California at Los Angeles (UCLA; N = 156 trios). Genotyping was conducted with the Illumina Human1M or Human1M-Duo BeadChip platforms. After applying quality control filters, association with ADHD was tested with 835,136 SNPs in 735 DSM-IV ADHD trios from 732 families. Results: Our smallest p value (6.7E-07) did not reach the threshold for genome-wide statistical significance (5.0E-08), but one of the 20 most significant associations was located in a candidate gene of interest for ADHD (SLC9A9, rs9810857, p = 6.4E-6). We also conducted gene-based tests of candidate genes identified in the literature and found additional evidence of association with SLC9A9. Conclusions: We and our colleagues in the Psychiatric GWAS Consortium are working to pool together GWAS samples to establish the large data sets needed to follow-up on these results and to identify genes for ADHD and other disorders. (Contains 3 figures and 5 tables.)
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Family-Based Genome-Wide Association Scan of Attention-Deficit/Hyperactivity Disorder
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Autor/in / Beteiligte Person: | Mick, Eric ; Todorov, Alexandre ; Smalley, Susan ; Hu, Xiaolan ; Loo, Sandra ; Todd, Richard D. ; Biederman, Joseph ; Byrne, Deirdre ; Dechairo, Bryan ; Guiney, Allan ; McCracken, James ; McGough, James ; Nelson, Stanley F. ; Reiersen, Angela M. ; Wilens, Timothy E. ; Wozniak, Janet ; Neale, Benjamin M. ; Faraone, Stephen V. |
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Zeitschrift: | Journal of the American Academy of Child & Adolescent Psychiatry, Jg. 49 (2010-09-01), Heft 9, S. 898-905 |
Veröffentlichung: | 2010 |
Medientyp: | academicJournal |
ISSN: | 0890-8567 (print) |
DOI: | 10.1016/j.jaac.2010.02.014 |
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