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Agammaglobulinemia and genetics.
In: Salem Press Encyclopedia of Health, 2023, S. 2
Online
Nachschlagewerk
Zugriff:
The disease is inherited as X-linked recessive. The defective gene is located on the X chromosome, which is one of two sex chromosomes (the other is the Y chromosome). In males, who have only one X chromosome, a defective gene causes agammaglobulinemia. In females, who have two X chromosomes, a defective gene on one chromosome is insufficient to cause disease but makes the woman a carrier capable of passing the abnormal gene to her children. Males cannot pass the disease to their sons, but they can pass the defective gene to their daughters, who will then be carriers. Rarely, spontaneous gene mutations cause the disease to appear without the mother being a carrier. These spontaneous mutations occur more often in the male gamete, and it has been observed that while the mother of a boy with X-linked agammaglobulinemia (XLA) has an 80 percent chance of being a carrier, the maternal grandmother is a carrier in only 25 percent of cases. XLA affects about three to six in one million males.
Titel: |
Agammaglobulinemia and genetics.
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Autor/in / Beteiligte Person: | Hawley, H. Bradford, MD |
Zeitschrift: | Salem Press Encyclopedia of Health, 2023, S. 2 |
Veröffentlichung: | 2023 |
Medientyp: | Nachschlagewerk |
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