Volltext verfügbar nach Anmeldung bzw. im Campus-Netz.
Cancer and genetics.
In: Salem Press Encyclopedia of Health, 2022-01-31, S. 3
Online
Nachschlagewerk
Zugriff:
Cancer is characterized by abnormal cell growth that leads to the invasion and destruction of healthy tissue by cells that meet certain criteria. Normal cells in the human body are continuously growing but are under normal cell control mechanisms. Cancer cells begin as normal cells that, as a result of genetic mutations, start to grow uncontrollably, escaping from the normal rules regulating cell growth and behavior. Cancer cells are characterized by six traits that differentiate them from normal healthy cells: cells that grow to abnormally large size; disregard for normal growth signals; lack of sensitivity to growth inhibition factors (antigrowth signals); avoidance of natural cell death (apoptosis); uninhibited replication; ability to form new vascular supply (angiogenesis); and ability for metastasis and invasion of neighboring tissues. Contact inhibition, in which cells contacting other cells prevent unrestrained growth, is lost in cancer cells. Normal cells also remain in one location, or at least in the same tissue, but malignant tumors, in their later stages, metastasize, allowing their cells to wander freely in the body, leading to the development of tumors in other organs. A final common feature is that cancer cells lose their normal cell shape.
Titel: |
Cancer and genetics.
|
---|---|
Autor/in / Beteiligte Person: | Tischauser, Leslie V., PhD ; Ness, Bryan, PhD ; Jones, Cheryl Pokalo, PhD |
Zeitschrift: | Salem Press Encyclopedia of Health, 2022-01-31, S. 3 |
Veröffentlichung: | 2022 |
Medientyp: | Nachschlagewerk |
Schlagwort: |
|
Sonstiges: |
|